毛囊单位样可移植假发的改进及组织相容性研究  

Histocompatibility of improved follicular unit-like wigs for hair transplantation

作　　者：王瑾[1] 胡志奇[1] 任婧[1] 冯传波[1] 张志丹[1] 苗勇[1] 

机构地区：[1]南方医科大学南方医院整形外科,广州510515

出　　处：《中华实验外科杂志》2014年第4期734-736,I0001,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（31170949）;广东省教育部产学研合作项目（2011B090400014）

摘　　要：目的改进毛囊单位样可移植假发并进行移植，观察其组织相容性。方法采用医用聚己内酯加工成毛囊单位样假发移植物。在新西兰白兔头皮处分别植入改进前后的假发移植物，定期取材行苏木素一伊红染色观察组织相容性，并计数炎性细胞进行比较。结果术后1周，改进后的假发移植物炎性反应较轻，炎性细胞较少[（122．67±4．55）个比（143．33±16．42）个，P〈0．05]：随后炎性细胞逐渐减少，成纤维细胞、胶原纤维增多，两组假发移植物组织相容性良好，炎性细胞计数差异无统计学意义[术后1月：（84．33±12．21）个比（75．00±9．65）个，P〉0．05；术后6个月：（11．00±2．19）个比（10．17±2．31）个，P〉0．05]。结论改进后的毛囊单位样可移植假发组织相容性良好，为长期移植研究奠定了良好的基础。Objective To improve follicular unit-like wigs, and observe the histocompatibility af ter transplantation. Methods Medical polycaprolactone matrix of hairpiece was processed into follicular u nit-like wig grafts and transplanted into the scalp of New Zealand white rabbits as experimental group. The scalp of New Zealand white rabbits was transplanted with the polypropylene matrix of hairpieces control group. The samples were regularly collected for Hematoxylin eosin staining to evaluate the histoeompatibili ty, and the inflammatory cells were counted and compared. Results At 1st week after transplantation, milder inflammatory cell infiltration was observed around wig implants in experiment group and the number of inflammatory cells was significantly less than that in control group （122.67 ±4. 55 vs. 143.33 ±16.42, P 〈 0. 05）. With decreasing number of inflammatory cells over time, more and more fibroblasts and colla gen fibers were emerged. Wig grafts remained good histocompatibility. There was no significant difference in the inflammatory cell count between two groups（ at 1 month ：84. 33 ± 12. 21 vs. 75.00 ± 9. 65,P 〉 0. 05; at 6 months ： 11.00 ± 2. 19 vs. 10.17 ± 2. 31, P 〉 0.05 ）. Conclusion hnproved follicular unit-fike wig has good histocompatibility without obvious adverse reactions.

关 键 词：毛发移植 脱发 组织相容性 

分 类 号：R318.08[医药卫生—生物医学工程]