GGCX(rs6738645)基因多态性与华法林稳定剂量的关系  

Research on correlation between GGCX(rs6738645) polymorphism and warfarin stable dose

作　　者：刘寅强[1] 杨百晖[1] 夏健明[1] 张学玉[1] 张桂敏[1] 

机构地区：[1]昆明医科大学第一附属医院心血管外科,云南昆明650032

出　　处：《重庆医学》2014年第10期1184-1186,共3页Chongqing medicine

基　　金：云南省创新团队计划资助项目(2011CI137)

摘　　要：目的探讨γ谷氨酰羧化酶(GGCX)(rs6738645)基因型在中国汉族人群中的分布情况,以及其基因多态性与瓣膜置换术后华法林稳定剂量的相关性。方法采用Snapshot技术检测228例研究对象GGCX(rs6738645)位点基因型,研究其基因型及等位基因频率;比较其中176例瓣膜置换术患者基因多态性与华法林稳定剂量的相关性。结果 228例研究对象中,GGCX(rs6738645)位点基因型TT、GT、GG分别为84例(36.84%)、122例(53.51%)、22例(9.65%),T和G等位基因的频率分别为63.60%和36.40%;176例瓣膜置换术后患者服用华法林达稳定状态,华法林日维持剂量GG组低于TT、GT组,组间比较差异有统计学意义(P<0.01);基因型3组间国际标准化比值(INR)、凝血酶原时间(PT)比较,差异无统计学意义(P>0.05)。结论中国汉族人群GGCX(rs6738645)基因多态性可能是瓣膜置换术后华法林个体剂量差异的影响因素。Objective To investigate the gamma glutamine carboxylase （GGCX ,rs6738645） genotype distribution in Chinese Han population and the correlation between GGCX （rs6738645） polymorphism and the warfarin stable dose in the patient after valve replacement .Methods The genotypes of 228 cases were detected by the Snapshot technology in order to explore the genotype and allele frequencies .The correlation between the gene polymorphism in 176 cases after valve replacement and the stable dose of warfa-rin was compared .Results In total of 228 research subjects ,the number of TT ,GT and GG genotype were 84（36 .84% ） ,122 （53 .51% ） and 22（9 .65% ） .The frequencies of T and G allele were 63 .60% and 36 .40% respectively ;in 176 patients after the valve replacement ,the maintenance stable dose of warfarin was lower in GG group than in the TT and GT groups ,the differences between the groups showed statistical significance （P＆lt;0 .01） .The PT value and INR value had no statistical difference among 3 genotype groups（P＆gt;0 .05） .Conclusion The GGCX（rs6738645） polymorphism in Chinese Han population may be the influencing factor of warfarin individual dose difference in the patients after valve replacement .

关 键 词：γ谷氨酰羧化酶 基因多态性 华法林 心脏瓣膜假体植入 

分 类 号：R97[医药卫生—药品]