Notch信号通路在哮喘及T淋巴细胞调节中的作用研究进展  

Research Progress of the Roles of Notch Signaling Pathway in Asthma and T Lymphocytes Regulation

作　　者：强巴措珍[1,2] 刘瀚旻[1] 

机构地区：[1]四川大学华西第二医院儿科,成都610041 [2]拉萨市人民医院儿科

出　　处：《中华妇幼临床医学杂志（电子版）》2014年第2期117-120,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省科技厅科技支撑计划项目(2013SZ0040)~~

摘　　要：Notch信号通路参与多种组织细胞的分化、成熟过程,尤其在T淋巴细胞的分化过程中起了决定性作用。近年来,大量研究表明,Notch信号通路参与支气管哮喘(BA)发病的整个病理过程,包括气道炎症、气道高反应、气道重塑及气道血管重塑。笔者拟就Notch信号通路在BA和T淋巴细胞调节中的作用,进行综述如下。Notch signaling pathway involves in cell differentiation process in a lot of tissues, especially playing an important role in T lymphocytes differentiation process.Recently,many reports have demonstrated that the Notch signaling pathway involves in the whole pathogenesis of bronchial asthma（BA） pathological process,including airway inflammation,airway hyperresponsiveness,airway remodeling and vascular remodeling of the airway.This paper summarizes the roles of Notch signaling pathway in BA and T lymphocyte regulation.

关 键 词：NOTCH信号通路 T淋巴细胞 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]