树枝状聚合物在双模态分子影像探针制备中的作用及研究进展  

The function and research progress of dendrimer on preparing bimodal molecular imaging probe

作　　者：徐宏艳[1] 张玉民[1] 褚丽萍[1] 

机构地区：[1]北京协和医学院中国医学科学院放射医学研究所,天津市放射医学与分子核医学重点实验室,天津300192

出　　处：《国际放射医学核医学杂志》2014年第2期96-100,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81171371,51203189,51303213）;天津市自然科学基金（13JCZDJC28100）;协和青年基金和中央高校基本科研业务费专项资金（3332013045）;中国医学科学院放射医学研究所学科发展基金（SF1314）

摘　　要：随着医疗水平的不断提高,人们对疾病的早期诊断和准确定位的要求越来越高.近年来,PET/CT和SPECT/CT已广泛应用于临床.为了能够在早期精确诊断的同时准确定位病灶,双模态成像方式备受科研人员和临床工作者的关注.双模态分子影像学的发展除了需要先进的成像设备外,最关键的是开发新型且高效的双模态成像探针.树枝状高分子纳米材料由于其结构均一,粒径可控,同时表面具有大量活性基团可用于连接多种分子探针,是一类潜在的双模态分子探针载体.该文就树枝状聚合物作为双模态探针载体,在光学成像/MRI、SPECT/CT及CT/MRI等成像领域中的应用研究进行相关的介绍.With the continuous improvement of the recent medical,people＇s demand for the early diagnosis and accurate localization of the disease have been increased.Recently,the PET/CT and SPECT/ CT have been widely used in clinic.In order to accurately locate lesions and diagnose the disease at the same time,the bimodal molecular imaging have been widely concerned by the researchers and clinical scientists.Other than the advanced imaging equipment,the most important for the bimodal molecular imaging is to develop new and efficient bimodal molecular imaging probes.Dendrimer nanomaterial is a potential bimodal molecular imaging probe vector because of its uniform structure,controllable particle size,and meanwhile the surface with a large number of active groups which can be used to connect multiple molecular probes.This paper introduced the application of dendrimer nanomaterial used as bimodal molecular imaging probe vector in optical imaging/MRI,SPECT/CT and CT/MRI.

关 键 词：双模态分子影像 树枝状聚合物 纳米载体 

分 类 号：R817.4[医药卫生—影像医学与核医学]