核素分子显像监测胚胎干细胞及诱导性多潜能干细胞移植的研究进展  

Advances in radionuclide imaging of monitoring embryonic stem cells and induced pluripotent stem cells transplantation

作　　者：吕靖[1] 张一帆[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院核医学科,200025

出　　处：《国际放射医学核医学杂志》2014年第2期106-109,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81171367,30570525）;上海市教委科研创新项目（12YZ041）

摘　　要：胚胎干细胞（ESCs）具有分化成多种细胞的能力,而由转录因子转染体细胞获得的诱导性多潜能干细胞（iPSCs）具有与ESCs相似的生物学特性,且不涉及伦理学相关问题,在干细胞治疗领域得到广泛的应用.近年来,干细胞移植治疗的分子影像学监测得到了快速发展,并取得了显著的成果.该文仅就核素分子显像监测ESCs及iPSCs移植的研究进展进行综述.Embryonic stem cells （ESCs） possess the ability to differentiate into various cell types.Induced pluripotent stem cells （iPSCs） are a type of pluripotent stem cell genetically reprogrammed from somatic cells,which have similar biological features of natural pluripotent stem cells,such as ESCs.iPSCs have been widely used in stem cell therapy without any drawbacks of ethical issues.In recent years,there is a growing body of studies concerning molecular imaging of monitoring stem cells transplantation and made significant achievements.This review will be focused on the updated application of radionuclide imaging in monitoring of ESCs and iPSCs transplantation.

关 键 词：干细胞移植 多潜能干细胞 放射性核素显像 分子影像学 

分 类 号：R817.1[医药卫生—影像医学与核医学]