稀土二氧化铈在生物领域的最新研究进展  

Recent progress of rare earth cerium oxide nanoparticles applied in biology

作　　者：徐灿[1,2] 曲晓刚[1,2] 

机构地区：[1]稀土资源利用国家重点实验室 [2]中国科学院长春应用化学研究所化学生物学实验室,长春130022

出　　处：《中国科学：化学》2014年第4期506-520,共15页SCIENTIA SINICA Chimica

基　　金：国家重点基础研究发展项目(2011CB936004);国家自然科学基金(21210002,91213302)支持

摘　　要：氧化铈纳米粒子因其优异的催化活性而一直以来备受关注.它的催化性质来源于表面铈离子可以快速地进行Ce4+和Ce3+转变,能够根据环境很容易地接受或失去电子.长久以来,其应用均集中在工业催化方面.然而近年来,它被发现具有多种生物酶,如超氧化物歧化酶、过氧化氢酶、磷酸酶、过氧化物酶和氧化酶等的模拟活性,以及具有羟基自由基及氮氧化物自由基清除的能力.这些多重酶活性使其在生物方面有着众多极具前景的潜在应用价值.目前,在生物领域其已被开发用于生物检测、疾病诊断及治疗、药物载体及生物支架等方面.本文主要介绍其多种生物酶活性、活性原理,及在生物领域中的最新研究进展.Cerium oxide nanoparticles received much attention because of its excellent catalytic activities. The activities derive from the quick and expedient mutation of the oxidation state between Ce4＋ and Ce3＋. The cerium ions have the ability to easily and drastically adjust its electronic configuration to best fit its immediate environment. Being mature engineer nanoparticles with various industrial applications, recently, the cerium oxide nanoparticles were found to have multi-enzyme （including superoxide oxidase, catalase, oxidase, peroxidase etc.） mimetic properties and have hydroxyl radical scavenging and nitric oxide radical scavenging abilities. It has emerged as a fascinating and lucrative material in biological field including bioanalysis, biomedicine, drug delivery, bioscaffold and so on. This review will provide a comprehensive introduction to the catalytic mechanisms, the multi-enzyme like activities, and the potential applications in biological fields of cerium oxide nanoparticles.

关 键 词：氧化铈纳米粒子 酶模拟 生物检测 逻辑门 药物载体 

分 类 号：O614.332[理学—无机化学] O643.36[理学—化学]