无机纳米晶-生物界面作用的分子机制  

Molecular interaction for understanding the nanocrystalline-bio interface

作　　者：沈星灿[1,2] 张丽[1,2] 雷文琪 纪仕辰[1,2] 梁宏 

机构地区：[1]药用资源化学与药物分子工程教育部重点实验室 [2]广西师范大学化学与药学学院,桂林541004

出　　处：《中国科学：化学》2014年第4期611-624,共14页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(21161003;21364002);广西自然科学基金杰出青年基金(2013GXNSFGA019001);广西自然科学基金(2012GXNSFDA053007;2011GXNSFA018044);教育部新世纪优秀人才支持计划;广西十百千人才项目;药用资源化学与药物分子工程教育部重点实验室主任基金(CMEMR2009-A12;CMEMR2012-A01);广西医药人才小高地基金(1105;1304)资助

摘　　要：无机纳米晶材料以其独特的光、电、磁、力学性质,成为疾病诊断与治疗功能的关键材料.本文总结了无机纳米晶的表面化学活性、离子释放性、晶相结构、晶格缺陷、表面吸附和表面修饰等与尺寸相关的理化性质与生物效应之间的关系.综述了无机纳米晶与蛋白质、磷脂生物膜间的界面相互作用,探讨了纳米晶-生物界面作用的分子机理.这有助于理解无机纳米晶的生物行为和毒理性质,指导设计安全、高效的纳米晶生物医学材料.The applications of engineered inorganic nanocarystalline for biomedical nanomaterials are gaining increased attention for their unique optical, electrical, magnetics and mechanical properties. In this paper, we summarize the correlating of size-dependent physicochemical properties of inorganic nanocarystalline, including of the interfacial reactivity, ion-released, lattice defect, crystalline phase structure, crystal face, surface adsorption and surface modific- ation. Focus is given on the correlating of these size-dependent physicochemical properties with the biological effect of inorganic nanocarystalline. The nano-bio interface molecular interaction between inorganic nanocarystalline and proteins, as well as biological membranes is also highlighted in detail. It is obvious that the investigation of the molecular mechanisms of nano-bio interactions is crucial for better understanding of biological behavior and nanotoxicity of inorganic nanocarystalline on nanoscale, and further guides the optimizing design of nano-biomaterials for diagnostics and therapeutics with high efficiency and high biocompatibility.

关 键 词：纳米晶 纳米-生物界面 相互作用 纳米毒性 理化性质 

分 类 号：TB383.1[一般工业技术—材料科学与工程]