不同种类黄体生成素的应用对辅助生殖结局的影响  

Effects of different types of luteinizing hormone supplements on outcomes of assisted reproductive technique

作　　者：黄晓虹[1] 杨洁[1] 肖国宏[1] 刘见桥[1] 杜红姿[1] 张伟良[1] 华七妹[1] 

机构地区：[1]广州医科大学附属第三医院生殖医学中心,广东省生殖医学重点实验室,广东广州510150

出　　处：《广州医学院学报》2013年第5期17-19,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的：探讨不同种类的黄体生成素（LH）在辅助生殖控制性超排卵过程中的作用.方法：选择2011年6～9月在广州医科大学第三附属医院生殖医学中心进行助孕的200个周期,使用GnRH-a长方案治疗.全部患者以卵泡刺激素、（FSH）启动,若超排卵第7天的血LH≥0.6 U/L,按原方案治疗;血LH＜0.6 U/L者,则随机添加重组人黄体生成素（r-LH）或尿促性素（HMG）75 IU/d至HCG日,按患者的用药方案分为A组（FSH＋r-LH）、B组（FSH）和C组（FSH＋HMG）.观察获卵数、受精率、卵裂率、优胚率、种植率和妊娠率.结果：C组获卵数为（9.97±6.41）个,少于A组的（11.91±6.41）个和B组的（14.13±6.52）个（P＜0.05）.A、B、C组妊娠率分别为52.87%、69.23%、52.45%,B组妊娠率显著高于其他两组（P＜0.05）.结论：不同种类LH的应用会影响超排卵结局和辅助生殖助孕结局,使用LH应谨慎并且有针对性.Objective： To investigate the effects of different types of luteinizing hormone （LH） supplements on the outcomes of assisted reproductive technology （ART）. Methods： We recruited 200 patients who underwent ART between June and September 2011 for prolonged therapy with GnRH-a in Reproduction Medicine Center, The Third Affiliated Hospital of Guangzhou Medical University. Ovulation was initiated with follicular stimulating hormone （FSH）. Patients were on maintenance of the previous protocol in case of an LH of 0.6IU/L or higher. Patients with an LH of 0. 6IU/L or lower were subsequently allocated to receive either 75IU/d recombinant luteinizing hormone （r-LH, group FSH ＋ r-LH） or human menotropin （HMG, group FSH ＋ HMG） to the day at which HCG could be detected. This assessment of the oocyte retrieval and the rates of fertilization, cleavage, high-quality embryo, implantation and pregnancy. Results： Group FSH ＋ HMG had the lowest yield of oocyte retrieval compared with that of groups FSH and FSH ＋ r-LH [ （9.97 ±6.41 ） vs. （11.91± 6.41 ） and （14.13 ± 6.52）, both P 〈0.05 ] 1. Group FSH （69.23%） was associated with a significantly higher rate of pregnancy compared with group FSH ＋ r-LH （52. 87%） and group FSH ＋ HMG （52. 45%）. Conclusion： The administration of different types of LH supplements accounts for altered outcomes of controlled ovarian hyperstimulation and ART, which calls for prudent and targeted administration of LH.

关 键 词：黄体生成素 辅助生殖 超排卵 

分 类 号：R527[医药卫生—内科学]