β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly  

作　　者：Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ 

机构地区：[1]Erasmus Medical Center,Room Ee 530b,Doctor Molewaterplein 50,3015 GE Rotterdam

出　　处：《中国神经肿瘤杂志》2013年第4期235-235,共1页Chinese Journal of Neuro-Oncology

摘　　要：Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomasRecent in vitro studies highlighted G protein-coupled receptor kinase （GRK）2 and β- arrestins as important players in driving somatostatin receptor （SSTR） desensitization and trafficking. Our aim was to characterize GRK2 and β-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog （SSA） treatment in GH- secreting adenomas （GHomas）. We evaluated mRNA expression of multiple SSTRs, GRK2, β-arrestin 1, and β-arrestin 2 in 41 pituitary adenomas （31 GHomas, 6 nonfunctioning [NFPAs], and 4 prolactinomas [PRLomas]）. Within the GHomas group, mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.

关 键 词：G蛋白偶联受体激酶 生长抑素受体 垂体腺瘤 治疗作用 类似物 调节作用 患者 肥大 

分 类 号：Q257[生物学—细胞生物学] Q513.2