Resistant prolactinoma:Is it monoclonal or polyclonal?  

作　　者：Kumar KV Prusty P 

机构地区：[1]Department of Endocrinology,Comm Hospital

出　　处：《中国神经肿瘤杂志》2013年第4期241-241,共1页Chinese Journal of Neuro-Oncology

摘　　要：Prolactinomas are solitary benign neoplasms and resistance to dopamine agonists occur in a small percentage of prolactinomas.Multiple pituitary adenomas are reported in less than 1%of pituitary adenomas and rarely result in resistant prolactinoma.We recently encountered an interesting patient of hyperprolactinemia with multiple pituitary microadenomas.Dopamine agonist use resulted in prolactin normalization and subsequent pregnancy resulted in drug withdrawal.Repeat evaluation after delivery showedProlactinomas are solitary benign neoplasms and resistance to dopamine agonists occur in a small percentage of prolactinomas. Multiple pituitary adenomas are reported in less than 1% of pituitary adenomas and rarely result in resistant prolactinoma. We recently encountered an interesting patient of hyperprolactinemia with multiple pituitary microadenomas. Dopamine agonist use resulted in prolactin normalization and subsequent pregnancy resulted in drug withdrawal. Repeat evaluation after delivery showed a macroprolactinoma and dopamine agonist therapy resulted in biochemical cure without reduction in tumor size. We report the case for its presentation with multiple microadenomas progressing to macroprolactinoma suggesting polyclonal in origin.

关 键 词：泌乳素 多克隆 单克隆 受体激动剂 垂体腺瘤 良性肿瘤 多巴胺 克隆表达 

分 类 号：Q453[生物学—生理学] Q55