粉刺治疗仪治疗寻常痤疮的临床研究  

An acne-clearing device for the treatment of acne vulgaris： a clinical study

作　　者：苏惠春[1] 程波[1] 刘晶晶[2] 王育英[2] 

机构地区：[1]福建医科大学附属第一医院皮肤科,福州350005 [2]福建医科大学附属协和医院皮肤科

出　　处：《中华皮肤科杂志》2014年第4期281-283,共3页Chinese Journal of Dermatology

摘　　要：目的评价粉刺治疗仪治疗寻常痤疮的疗效和安全性。方法73例轻中度寻常痤疮患者，采用双中心随机单盲自身阴性对照平行试验方法，从每例患者面部取2个类似的炎性丘疹，分别用粉刺治疗仪（输出温度为46℃～50℃）和无热源的安慰仪器进行治疗（分别为治疗组和对照组），共治疗3次，每次3min，头2次在第1天，2次间隔1-12h，第3次在第2天，与上1次治疗间隔18—48h。于治疗前、开始后第1、5和14天分别记录受试者两个皮损的颜色、直径、不良反应等，并对每个皮损进行评分，比较治疗结果。结果治疗组73例治疗后第1、5和14天分别有66例（90．4％）、73例（100．0％）、72例（98．6％）有效，27例（37．0％）、64例（87．7％）、72例（98．6％）显效，与对照组有效率和显效率比较，差异均有统计学意义。治疗组皮损红肿开始消退的平均时间为19．51h，比对照组提前82．41h；治疗组完全痊愈的平均时间为7．15d，比对照组提前5．07d。结论粉刺治疗仪治疗轻中度痤疮安全有效，可快速缓解炎症痤疮症状，缩短皮损红肿消退时间和皮损痊愈时间。Objective To evaluate the efficacy and safety of an acne-clearing device in treating acne vulgaris. Methods A bicenter, randomized, single-blinded, placebo-controlled, parallel-group study was conducted. Seventy-three patients with mild to moderate acne vulgaris were enrolled for the trial. Two similar, clinically matched inflammatory papules were selected from each patient, and divided into a test group and a control group to be treated with an acne-clearing device with an output temperature of 46 - 50℃ and a control device without heat source respectively, for three sessions with the interval varying from 1 to 12 hours between the first two sessions and from 18 to 48 hours between the last two sessions. Every treatment lasted three minutes. Lesional color and size were recorded before and on day 1, 5 and 14 after the first treatment. Side effects were also recorded for the evaluation of safety. Results Clinical improvement was observed in 66 （90.4%）, 73 （100.0%） and 72 （98.6%） patients, and marked improvement in 27 （37.0%）, 64 （87.7%） and 72 （98.6%） patients on day 1, 5 and 14 after the first treatment, respectively. Significant differences existed between the control and test group in improvement rate on day 1 and 5, and in marked improvement rate on all the three time points （all P 〈 0.01）. The average time taken for erythematous swelling to begin to subside and time for lesions to completely heal were 19.51 hours and 7.15 days respectively in the test group, significantly shorter than those in the control group by 82.41 hours and 5.07 days respectively. Conclusions The acne-clearing device proves to be effective and safe for the treatment of mild to moderate acne vulgaris, which can rapidly relieve the inflammation in ache, shorten the time required for erythematous swelling to subside and for lesions to completely heal.

关 键 词：痤疮 寻常 物理治疗技术 高温 诱发 随机对照试验 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]