多糖的药代动力学研究进展  

Research progresses of pharmacokinetics of polysaccharides

作　　者：易阳[1] 王宏勋[1] 何静仁[1] 

机构地区：[1]武汉轻工大学食品科学与工程学院,湖北武汉430023

出　　处：《药学学报》2014年第4期443-449,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(31301416);武汉轻工大学引进(培养)人才科研启动项目(2013RZ03)

摘　　要：药代动力学分析在天然活性产物研究领域方兴未艾,但多糖的相关研究却较为薄弱。综述近年来涉及多糖药代动力学的研究文献,归纳色谱法、同位素标记法、分光光度法、荧光光度法和生物测定法在多糖药代动力学分析中的应用,表征多糖在实验动物体内的吸收、分布、降解和排泄行为,探讨其理化特征、给药剂量及方式对药代动力学特征的影响,以期为相关研究提供参考。Pharmacokinetic analysis has attracted more and more attentions in the research field of bioactive natural product. However, there is limited study on the pharmacokinetics of polysaccharides. This paper focused on the research progresses of pharmacokinetics of polysaccharide, summarized the applications of chromatography, isotope labeling method, spectrophotometry, fluorospectrophotometry and biological assay in the analysis of polysaccharide pharmacokinetics, elucidated the behaviors of absorption, distribution, degradation and excretion of polysaccharide in experimental animals, and revealed the effects of physicochemical characteristic, administration dose and route on the pharmacokinetic properties of polysaccharide, which could be served as a reference for the related works.

关 键 词：多糖 药代动力学 检测 

分 类 号：R917[医药卫生—药物分析学]