血清内脂素与妊娠期糖尿病并发子痫前期的关系  

Relationship between serum visfatin and gestational diabetes complicated preeclampsia

作　　者：刘楼[1] 许建娟[1] 孙丽洲 

机构地区：[1]南京医科大学附属无锡妇幼保健院产科,江苏省214002 [2]江苏省妇幼保健院产科

出　　处：《江苏医药》2014年第6期666-668,共3页Jiangsu Medical Journal

基　　金：无锡市医院管理中心医学技术联合攻关项目(YGZX1220)

摘　　要：目的探讨血清内脂素与妊娠期糖尿病(GDM)并发子痫前期的关系。方法 ELISA法检测GDM并发子痫前期孕妇(A组,12例)、GDM无子痫前期孕妇(B组,30例)和正常孕妇(C组,50例)外周血清内脂素浓度;并测定三组孕妇的平均动脉压(MAP)、空腹胰岛素(FIns)、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC),计算胰岛素抵抗指数(HOMA-IR)和体重指数(BMI),分析血清内脂素水平与GDM并发子痫前期的关系。结果 A组血清内脂素、FIns和HOMA-IR均高于B组(P<0.05),B组高于C组(P<0.01)。多元回归分析显示,血清FIns水平是影响血清内脂素的重要因素。结论 GDM并发子痫前期孕妇血清内脂素水平明显升高,且与胰岛素抵抗有关。Objective To study the relationship between serum visfatin and gestational diabetes complicated with preeclampsia （GDM-PE）. Methods Serum level of visfatin was examined in the pregnant women with GDM-PE（group A, 12 cases） ,GDM without PE（group B, 30cases） and normal pregnancy（group C, 50 cases）. The mean arterial pressure （MAP）, fasting blood glucose（FBG）, triglyceride（TG）, total cholesterol （TC） and fasting insulin （Fins） were detected as well, and insulin resistance index（HOMA-IR） and body mass index（BMI） were calculated. The relationship between serum visfatin and GDM-PE was analyzed. Results Serum levels of visfatin and Fins and HOMA IR were higher in group A than those in group B（P〈0. 05） ,which were higher in group B than those in group C（P〈0.01）. Multiple regression analysis showed that serum level of Fins was an important factor to influence serum visfatin. Conclusion Serum visfatin level is significantly elevated in the pregnant women with GDM-PE,which is related with insulin resistance.

关 键 词：内脂素 妊娠期糖尿病 子痫前期 

分 类 号：R714[医药卫生—妇产科学]