沙门菌对酸压力的应答及其与毒力的关系  

Acid stress response of Salmonella and its relationship with virulence-A review

作　　者：任洁[1] 赵明文[1] 姚玉峰[2] 

机构地区：[1]南京农业大学生命科学学院,江苏南京210095 [2]上海交通大学医学院基础医学院病原生物学教研室,上海200025

出　　处：《微生物学报》2014年第4期367-375,共9页Acta Microbiologica Sinica

基　　金：国家自然科学基金(31270173);国家"973项目"--国家重点基础研究发展计划(2009CB522605)~~

摘　　要：沙门菌(Salmonella spp.)作为肠道细菌,必须克服胃中酸性环境,才能进一步入侵宿主肠道上皮细胞。已有的研究表明,沙门菌通过进化出多种应答机制,增强自身在酸性环境下的生存。本文回顾了沙门菌的耐酸特性,阐述了抵御酸压力时的几种应答机理,包括胞内pH的维持、调控酸激蛋白的时序表达以及细胞膜特性的改变。这些研究对人类了解和控制沙门菌的感染具有重要的指导意义。As successful enteric bacteria, Salmonella spp. has to overcome the extreme acid condition in the stomach before invading into host intestinal epithelial cells. Salmonella spp. has evolved an adaptation to its replieative niche in the acidic environment. This review summarizes acid resistant characteristics of Salmonella, and introduces several mechanisms to acid resistance, including keeping internal pH homeostatic, synthesizing acid shock protein through several regulatory pathways and altering membrane character. The achievements will be significant for understanding and controlling Salmonella infections in the future.

关 键 词：沙门菌 氨基酸脱羧系统 酸激蛋白 

分 类 号：Q93-3[生物学—微生物学]