四川大学华西医院健康体检人群患亚临床甲状腺功能减退症的横断面调查  

Subclinical Hypothyroidism of Health Check-up Population of West China Hospital, Sichuan University: A Cross-sectional Study

作　　者：秦恳[1] 唐国华[1] 李李[1] 张帆[1] 吴琴琴[1] 杨英[1] 黄燕[1] 廖晓阳[2] 

机构地区：[1]四川大学华西医院健康管理中心,成都610041 [2]四川大学华西医院全科医学中心,成都610041

出　　处：《中国循证医学杂志》2014年第4期404-407,共4页Chinese Journal of Evidence-based Medicine

摘　　要：目的 调查2011～2012年四川大学华西医院健康体检人群亚临床甲状腺功能减退症（简称亚甲减）的患病情况，并探讨性别与甲减和代谢综合征（MS）的关系。方法 对2011～2012年在四川大学华西医院进行健康体检并行甲状腺功能检测的人群进行调查。其内容包括采集患者的病史、血压、身高、体重、甲状腺功能、空腹血糖、甘油三酯和高密度脂蛋白胆固醇等。统计分析采用SPSS 18.0软件。结果 共纳入11 976名接受了甲状腺功能检测者，其中男性7 488人，女性4 488人。该11 976名体检人群中共发现亚甲减患者1 820例，占15.20%。其中男性884例（患病率11.81%），女性936例（患病率20.86%），女性患病率明显高于男性（P〈0.01）。60岁以上人群的患病率高于其他年龄段。共发现MS患者1 145例，其中男性1 005例（患病率13.42%），女性140例（患病率3.12%），男性患病率明显高于女性（P〈0.01）。MS组的亚甲减患病率最高，正常代谢组的患病率最低（P〈0.01）。MS组的TSH水平最高，正常代谢组最低（P〈0.01）。结论 健康体检人群中亚甲减患病率较高，且亚甲减患者发生MS的可能性明显增高。ObjectiveTo investigate the prevalence of subclinical hypothyroidism （SCH） in health check-up population of West China Hospital of Sichuan University from 2011 to 2012 and to discuss the relationship between SCH and metabolic syndrome （MS）. MethodsThose who received thyroid function tests and health examination in the West China Hospital of Sichuan University from 2011 to 2012 were enrolled in the study. The data of medical history, blood pressure, height, weight, thyroid function, TG, HDL-C, FPG were collected. All data were analyzed by SPSS 18.0 software. ResultsA total of 11 976 persons （7 488 male and 4 488 female） received thyroid function tests. There were 1 820 persons （884 males and 936 females, 15.20%） who suffered from SCH. The SCH prevalence was significantly higher in females （20.86%） than that in males （11.81%） （P〈0.01）. The people over 60 years old had the highest SCH prevalence. There were 1 145 persons （1 005 males and 140 females） suffered from MS among all 11 976 persons. The MS prevalence was significantly higher in males （13.42%） than that in females （3.12%） （P〈0.01）. The SCH prevalence of the MS group was higher, which in the health group was lower （P〈0.01）. The TSH level in the MS group was higher, while it was lower in the health group. ConclusionThe prevalence of SCH is higher in health check-up population; and SCH apparently increases the risk of morbidity of MS.

关 键 词：亚临床甲状腺功能减退症 代谢综合征 患病率 横断面调查 

分 类 号：R581.2[医药卫生—内分泌]