心脑合病危险因素的横断面调查  

Risk Factors of Angina Pectoris Complicated with Atherosclerotic h rombotic Cerebral Infarction in China: A Cross-sectional Study

作　　者：王建华[1] 肖蕾[2] 张哲[2] 何丽云[3] 闫世艳[3] 王鑫[3] 杨关林[1] 

机构地区：[1]辽宁中医药大学,沈阳110032 [2]辽宁中医药大学附属医院,沈阳110032 [3]中国中医科学院中医基础医学研究所临床评价中心,北京100700

出　　处：《中国循证医学杂志》2014年第4期408-413,共6页Chinese Journal of Evidence-based Medicine

基　　金：2008年度中医药行业科研专项项目(编号:200807061)

摘　　要：目的通过与冠心病心绞痛、动脉粥样硬化性血栓性脑梗死危险因素的对比,探讨冠心病心绞痛合并动脉粥样硬化性血栓性脑梗死(简称心脑合病)的危险因素,为心脑合病的预防提供依据。方法采用横断面调查方法,纳入冠心病心绞痛、动脉粥样硬化性血栓性脑梗死和心脑合病患者的危险因素资料,运用SPSS 17.0软件对危险因素先进行单因素分析,然后应用logistic回归模型筛选心脑合病的独立危险因素。结果最终纳入冠心病心绞痛1?002例、动脉粥样硬化性血栓性脑梗死患者963例和心脑合病患者982例。三种疾病在患者年龄(P=0.000?0)、性别(P<0.000?1)、静息生活方式(P=0.000?0)、体重指数(BMI)(P=0.000?0)、糖尿病(P=0.001?9)、高血压(P<0.000?1)、糖尿病合并高血压(P<0.000?1)、吸烟(P<0.000?1)、饮酒(P<0.000?1)以及合并三种以上危险因素(P=0.000?0)等方面,其差异均有统计学意义。logistic多元回归分析显示,患者年龄[OR=1.690,95%CI(1.420,2.012)]、高血压[OR=1.558,95%CI(1.312,1.850)]、BMI异常[OR=1.356,95%CI(1.158,1.587)]及静息生活方式[OR=1.319,95%CI(1.107,1.572)]是心脑合病的独立危险因素。结论高龄、高血压、BMI异常和有静息生活方式的人易患心脑合病,应加强干预。ObjectiveTo compare the risk factors of angina pectoris and atherosclerotic thrombotic cerebral infarction, and to study the possible risk factors of angina pectoris complicated with atherosclerotic thrombotic cerebral infarction （XNHB abbr. in Chinese） and provide the basis for the prevention of XNHB. MethodsClinical epidemiological cross-sectional survey methods were used. Information of angina pectoris patients, atherosclerotic thrombotic cerebral infarction patients and XNHB patients were collected. The statistical software SPSS 17.0 was used to analyze the single risk factors, and then logistic regression analysis was used to filter the independent risk factors of XNHB. Results1 002 cases of angina pectoris, 963 cases of atherosclerotic thormbotic cerebral infaction and 982 cases of XNHB were included. There were significant differences among the three diseases in the following index： age （P=0.000 0）, gender （P〈0.000 1）, resting lifestyle （P=0.000 0）, body mass index （BMI） （P=0.000 0）, diabetes （P=0.001 9）, hypertension （P〈0.000 1）, diabetes complicated with hypertension （P〈0.000 1）, smoking （P〈0.000 1）, alcohol consumption （P〈0.000 1）, and the combination of more than 3 risk factors （P=0.000 0）. Age （OR=1.690, 95%CI 1.420 to 2.012）, hypertension （OR=1.558, 95%CI 1.312 to 1.850）, abnormal BMI （OR=1.356, 95%CI 1.158 to 1.587） and resting lifestyle （OR=1.319, 95%CI 1.107 to 1.572） were shown as the independent risk factors of XNHB filtering by logistic multiple regression analysis. ConclusionThe elderly with hypertension, abnormal BMI or live a resting way of life are more likely to have XNHB, so positive control of risk factors should be needed.

关 键 词：心脑合病 冠心病心绞痛 动脉粥样硬化性血栓性脑梗死 危险因素 横断面调查 

分 类 号：R541.4[医药卫生—心血管疾病]