亚洲健康人群CYP2C19基因型发生率的合并分析  

Genotype Frequencies of CYP2C19 in Healthy Asian Populations: A Synthetic Analysis

作　　者：张爱玲[1,2] 胡欣[1] 杨莉萍[1] 

机构地区：[1]卫生部北京医院药学部,药物临床风险与个体化应用评价北京市重点实验室,国家呼吸系统疾病临床医学研究中心,北京100730 [2]沈阳药科大学药学院,沈阳110016

出　　处：《中国循证医学杂志》2014年第4期427-434,共8页Chinese Journal of Evidence-based Medicine

基　　金：中国老年人综合评估和医疗服务体系建立及推广(编号:201002011)

摘　　要：目的对亚洲健康人群CYP2C19基因型发生率进行合并分析,为个体化药物治疗和药物基因组学研究提供依据。方法计算机检索PubMed、EMbase、h e Cochrane Library(2013年第2期)、CNKI、WanFang Data、VIP和CBM数据库,文献检索时限均从建库至2013年8月,纳入研究CYP2C19亚洲健康人群基因型发生率的相关文献。按照纳入与排除标准筛选文献、提取数据后进行合并分析。结果共纳入36篇文献,包含15个国家的9?693例亚洲健康人CYP2C19基因型的信息。按东亚(中国、韩国、日本)、东南亚(泰国、缅甸、越南、新加坡、马来西亚和印度尼西亚)、南亚(印度)和西亚(巴勒斯坦、黎巴嫩、伊朗、土耳其和约旦)分区域进行分析。研究结果显示CYP2C19*1/*1、*1/*2、*1/*3、*2/*2、*2/*3和*3/*3基因型发生率:在中国人群(n=4?105)中分别为37.2%、41.4%、6.7%、9.9%、4.1%和0.7%;在东亚人群(n=6?198)中分别为36.4%、39.1%、8.8%、9.5%、4.9%和1.3%;在东南亚人群(n=1?933)中分别为44.9%、41.1%、4.7%、7.0%、1.8%和0.6%;在南亚人群(n=361)中分别为43.5%、42.9%、0.3%、12.7%、0.6%和0.0%;在西亚人群(n=1?201)中分别为77.8%、18.9%、0.3%、2.6%、0.1%和0.3%;在亚洲全部人群(n=9?693)中分别为43.5%、37.1%、6.6%、8.3%、3.5%和1.0%。结论 CYP2C19各基因型发生率在我国及亚洲不同区域之间均存在较大差异,且遗传变异受地域或环境的影响。ObjectiveTo analyze genotype frequencies of CYP2C19 in healthy Asian population, and to provide evidence-based data for further personalized drug therapy and pharmacogenomics research. MethodsLiterature was retrieved from digital databases of PubMed, EMbase, The Cochrane Library （Issue 2, 2013）, CNKI, WanFang Data, VIP and CBM from their established dates to August, 2013. According to the inclusion and exclusion criteria, the data of the allele frequencies of the gene were extracted, pooled, and analyzed. ResultsA total of 36 articles were included, involving 15 countries and 9 693 healthy populations. Analysis was conducted on regional features, by regions as China, East Asia （China, Korea and Japan）, Southeast Asia （Vietnam, Thailand, Malaysia, Singapore, Myanmar and Indonesia）, South Asia （India） and West Asia （Palestine, Lebanon, Iran, Turkey and Jordan）. The results showed that the genotype frequencies of ＊1/＊1, ＊1/＊2, ＊1/＊3, ＊2/＊2, ＊2/＊3 and ＊3/＊3 were 37.2%, 41.4%, 6.7%, 9.9%, 4.1% and 0.7% （Chinese, n=4 105）; 36.4%, 39.1%, 8.8%, 9.5%, 4.9% and 1.3% （East Asian, n=6 198）; 44.9%, 41.1%, 4.7%, 7.0%, 1.8% and 0.6% （Southeast Asian, n=1 933）; 43.5%, 42.9%, 0.3%, 12.7%, 0.6% and 0.0% （South Asian, n=361）; 77.8%, 18.9%, 0.3%, 2.6%, 0.1% and 0.3% （West Asia, n=1 201）; and 43.5%, 37.1%, 6.6%, 8.3%, 3.5% and 1.0% （Asian, n=9 693）. ConclusionThe present study suggests that there is a great difference on the genotype frequencies of CYP2C19 for different ethnic groups in China, and at different regions in Asia. Besides, genetic variation is impacted by geographical factors such as region and environment.

关 键 词：CYP2C19 基因型 发生率 亚洲 健康人 

分 类 号：R450[医药卫生—治疗学]