氟比洛芬聚丙烯酸树脂RL/RS固体分散体的制备  

Preparation of endragit RL /RS encapsulated flurbiprofen solid dispersion

作　　者：刘善峰 徐爱霞 李叶桓[3] 王海龙[3] 

机构地区：[1]沂南县中医院,山东沂南276300 [2]沂南县妇幼保健院,山东沂南276300 [3]济南大学医学与生命科学学院,山东济南250022

出　　处：《药学研究》2014年第3期155-157,161,共4页Journal of Pharmaceutical Research

基　　金：山东省教育厅科研发展计划项目(No.J10LF03);济南大学科研基金项目(No.XKY1209)

摘　　要：目的制备氟比洛芬固体分散体并考察其体外释药特性。方法以氟比洛芬为主药,分别以聚丙烯酸树脂Eudragit RL、RS及RL/RS混合物为载体,卵磷脂为乳化剂,以溶剂法制备固体分散体。以体外溶出半衰期t1/2为指标,优选固体分散体的最佳制备方法。结果氟比洛芬固体分散体的最佳处方比例为:药物∶载体=1∶9,RL∶RS=2∶1,卵磷脂浓度为0.2%。固体分散体体外溶出测定采用小杯法,测定波长为247 nm,分别采用紫外分光光度法和差示扫描热量法进行定量、定性分析。结论制备所得氟比洛芬固体分散体体外溶出缓慢、平稳、完全,达到提高生物利用度、12 h给药1次的缓释设计目的,可进一步制成其他剂型。Objective To preparing flurbiprofen solid dispersion and investigate its release behavior in vitro. Methods Solid dispersion of flurbiprofeu was prepared with solvent evaporation method, in which different carriers such as Eudragit RL,Eudragit RS or mixture of RL/RS as a skeleton and lecithin as emulsifier were used. The in vitro release behaviors and tl/2 were used to optimize the prescription and technique. Results The optimized formula of flurbiprofeu solid dispersion was ： drug ： carrier, RL ： RS ratio and lecithin concentration as 1：9,2：1, and 0. 2 % , respectively. The solid dispersion was de- termined by the method of dissolving pulp in vitro, the determination wavelength was 247 nm, the ultraviolet speetrophotome- try and differential scanning calorimetry for quantitative and qualitative analysis, respectively. Conclusion The prepared flurbiprofen solid dispersion in vitro release was slowly, steadily and completely. The higher bioavailability and effectiveness of drug for 12 hours indicated that the solid dispersion can be studied further more.

关 键 词：氟比洛芬 聚丙烯酸树脂RS RL 固体分散体 

分 类 号：R944.4[医药卫生—药剂学]