复方葛根胶囊对葡萄糖耐量低减小鼠糖耐量及胰岛素抵抗干预作用的研究  

Research of the Compound Puerarin Capsule on glucose tolerance and insulin resistance in IGT mice

作　　者：李津[1] 冯前进[1] 宋强[1] 杜道辉[2] 

机构地区：[1]山西中医学院,太原030024 [2]湖北省武汉市黄陂区人民医院,武汉430300

出　　处：《中华中医药杂志》2014年第4期1061-1063,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技支撑计划(No.2011BAI07B05);国家自然科学基金面上项目(No.30572297);山西省国际科技合作项目(No.2009081038;No.2011081057)~~

摘　　要：目的:通过观察复方葛根胶囊对D-半乳糖(D-gal)诱导的葡糖糖耐量低减(IGT)小鼠干预作用的影响,为临床应用和研究开发提供科学依据。方法:除空白对照组外,模型对照组、阳性药对照组、复方葛根胶囊小、中、大剂量组采用D-gal腹腔注射法诱导IGT,造模14d后,继续腹腔注射D-gal,同时给予相应药物灌胃,每天1次,共42d。干预结束后,进行口服葡萄糖耐量实验,测定血清空腹血糖及空腹胰岛素(FINS),并计算胰岛素抵抗指数(HOMA-IR)。结果:阳性药对照组、复方葛根胶囊小、中、大剂量组30、60、120min血糖值、FINS、HOMA-IR均低于模型对照组,差异有统计学意义(P<0.01),复方葛根胶囊大剂量组与阳性药对照组相比,血糖值、FINS、HOMA-IR差异无统计学意义。结论:复方葛根胶囊可能是通过改善胰岛素抵抗,从而对IGT小鼠起到干预作用,其作用机制还有待于进一步深入研究。Objective： In this research, to provide scientific basis for clinical application and research, by observing the intervention effect of the Compound Pueraria Capsule on D-galactose-induced IGT mice. Methods： Except for normal control group, IGT mice of model control group, positive control group, small, medium, and high-dose of Compound Pueraria Capsules group were adopted D-galactose by intraperitoneal injection. After 14 days, the mice were intraperitoneal injected D-galactose and intragastric administrated relative drugs, once a day, total 42 days. In the end, oral glucose tolerance test was tested, fasting glucose and fasting insulin, and insulin resistance index were calculated. Results： Positive control group, small, medium and high dose of Compound Pueraria Capsules group compared with the model group, glucose levels of 30min, 60min, 120min, FINS, HOMA-IR were lower than the model control group, the difference was statistically significant （P〈0.01）. High dose of Compound Pueraria Capsules group compared with the positive control group, the differences of blood glucose levels, FINS, HOMA-IR were not statistically significant. Conclusion： Compound Pueraria Capsules may improve insulin resistance and thus play an intervention effect in IGT mice, its mechanism still needs further study.

关 键 词：复方葛根胶囊 葡萄糖耐量低减 葛根素 葡萄糖耐量因子 胰岛素抵抗 

分 类 号：R259[医药卫生—中西医结合]