中药配伍雷公藤减肝毒性机制研究  

Study on the mechanism of attenuating hepatotoxicity of Tripterygium wilfordii through compatibility

作　　者：周聪[1] 周玲玲[1] 周学平[1] 

机构地区：[1]南京中医药大学,江苏省中药药效与安全性评价重点实验室,南京210023

出　　处：《中华中医药杂志》2014年第4期1167-1169,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81072749);教育部博士点基金项目(No.20103237110004);江苏省普通高校研究生科研创新计划~~

摘　　要：雷公藤具有抗炎、镇痛和全身免疫调节作用,在临床治疗风湿病中具有不可替代的功效。但是,雷公藤常见的肝毒性限制了其临床的广泛应用。随着现代医药学技术的发展,中药配伍作为中医用药的特色之一,更显合理性和科学性,其减肝毒性的机制也取得了深入的研究。文章对雷公藤的肝毒性机制及中药配伍减轻其肝毒性的作用机制作了概述,并针对中药配伍减毒机制的深入研究进行了展望。Tripterygium wilfordii Hook f. has been shown to possess multiple biological activities, such as anti- inflammation, analgesia and immunosuppressive activities, and it has irreplaceable therapeutic effect on rheumatism. However, its severe adverse effects, especially hepatotoxicity, limits the clinical application. Traditional Chinese compatibility, as acharacteristic of Chinese medicine, is much more rational and scientific. With the development of modern technology, the mechanism study on attenuating hepatotoxicity of Tripterygium wilfordii through compatibility gets penetrating progression. Review the compatibility applied in the attenuation of Tripterygium wilforii and its mechanism, this paper takes the suggestion on the studies of Chinese medical compatibility.

关 键 词：雷公藤 肝毒性 配伍减毒 机制 

分 类 号：R285[医药卫生—中药学]