对头孢菌素类抗生素皮肤敏感试验临床意义的探讨  

A review of skin test necessity required for cephalosporins

作　　者：丁天然[1] 张永信[2] 

机构地区：[1]复旦大学附属上海市公共卫生临床中心药剂科,上海201508 [2]复旦大学附属华山医院感染科,上海200040

出　　处：《上海医药》2014年第7期9-12,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：头孢菌素类抗生素是一类疗效和安全性好、临床应用广泛的抗菌药物,但由于可能引发过敏反应,故有学者认为须在注射给药前进行皮肤敏感试验(以下简称为"皮试")。但对头孢菌素类抗生素是否必须进行皮试、如何进行皮试和皮试的临床意义等问题,目前国内、外均还无定论。本文介绍头孢菌素类抗生素导致过敏反应发生的机制,归纳国外对临床使用头孢菌素类抗生素前进行皮试的必要性的研究结果,发现虽观点不一,但认为进行头孢菌素类抗生素皮试意义不大的依据较强。Cephalosporins, one of the most effective antibacterial agents with a wide clinical application, a signiifcant therapeutic effect and a high safety, is often abandoned by doctors due to concerns for allergy. Diagnostic skin tests are designed to screen patients with possibility of potential allergy. However, no conclusion has been demonstrated on their necessity. Therefore, researches and clinical experiences abroad are summarized in this article, in which more evidences showed that diagnostic skin tests for cephalosporins were not meaningful.

关 键 词：头孢菌素类抗生素 皮肤敏感试验 抗菌药物 

分 类 号：R978.11[医药卫生—药品] R969.3[医药卫生—药学]