甲硝唑对剖宫产切口感染患者血清白介素及其他炎性指标的影响  

Influence of metronidazole on serum interleukin and other inflammatory markers of patients with post caesarean wound infection

作　　者：马桂英[1] 蓝洁珍 邵茸[1] 

机构地区：[1]东莞市长安医院妇产科,广东东莞523843

出　　处：《海南医学院学报》2014年第5期687-690,共4页Journal of Hainan Medical University

基　　金：广东省新技术应用基金资助项目(gd2012827)~~

摘　　要：目的:研究甲硝唑对剖宫产切口感染患者血清白介素及其他炎性指标的影响。方法:124例剖宫产后切口感染患者随机分成两组,对照组和观察组各62例,对照组采用头孢类抗生素治疗,观察组在此基础上加甲硝唑。比较两组疗效及治疗前后血清白介素2、4、6、10(IL-2、IL-4、IL-6、IL-10)水平和其他炎症因子高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-a(TNF-α)、γ-干扰素(INF-γ),一氧化氮(NO)水平的差异。结果:观察组患者抗生素用药天数及住院时间显著短于对照组,治疗3d后体温及血浆白细胞水平低于对照组,差异有统计学意义(P<0.05)。治疗3、7d后观察组血清IL-2、IL-4、IL-6、IL-10水平和血清hs-CRP、TNF-α、INF-γ、NO水平均低于对照组,差异均有统计学意义(P均<0.05)。结论:甲硝唑能有效促进剖宫产切口感染患者恢复,降低血清白介素及其他炎性指标水平。Objective： To observation the influence of metronidazole on serum interleukin and other inflammatory markers of patients with post caesarean wound infection. Methods： A total of 124 cases of post caesarean wound infection were randomly divided into control group and observation group by half. Patients in control group were treated by cephalosporins, patients in observation group were treated by cephalosporins combined with metronidazole. Then the efficacy of two groups were compared, the levels of IL-2, IL-4, IL-6, IL-10 and hs-CRP, TNF-α, INF-γ, NO before and after treatment were also been compared. Results：The days of antibiotic treatment and hospitalization time of observation group were all longer than those of control group. On the 3rd day, temperature and plasma levels of white blood cells were all lower than of control group all P〈0. 05. On the 3rd, Ted day, the serum levels of IL-2, IL-4, IL- 6, IL-10 and hs-CRP, TNF-α, INF-γ, NO of observation group were all lower than those of control group,all P 〈 0. 05. Conclusion： Metronidazole could effectively improve patients with post caesarean wound infection to recover, and decrease the levels of serum interleukin and nther inflammatory markers.

关 键 词：剖宫产 切口感染 白介素 炎性指标 甲硝唑 

分 类 号：R719.8[医药卫生—妇产科学]