变应性鼻炎患者血清白细胞介素含量检测及临床价值  

Serum interleukin levels in allergic rhinitis patients and its clinical value

作　　者：阙镇如[1] 冉骞[1] 林丹琪[1] 张智斌[1] 蔡继一[1] 许玉[1] 黄钦辉[1] 

机构地区：[1]解放军第180医院耳鼻咽喉科,福建泉州362008

出　　处：《海南医学院学报》2014年第5期700-703,共4页Journal of Hainan Medical University

基　　金：泉州市科技局资助项目(2012z59)~~

摘　　要：目的:研究变应性鼻炎患者血清白细胞介素含量及临床价值。方法:选取在我院就诊的变应性鼻炎患者纳入研究的观察组,同期在我院接受体检的健康者纳入研究的对照组,检测血清白细胞介素-4(IL-4)、白细胞介素-5(IL-5)、白细胞介素-17(IL-17)、白细胞介素-33(IL-33)含量以及气道功能指标,并进行临床症状评分。结果:(1)观察组的IL-4、IL-5、IL-17、IL-33水平高于对照组;(2)观察组的最大呼气流速(PEF)、一秒率(FEV1/FVC%)均低于对照组,喷嚏、流涕、鼻塞、鼻痒评分均高于对照组;(3)血清IL-4、IL-5、IL-17、IL-33水平与PEF、FEV1/FVC呈负相关,与喷嚏、流涕、鼻塞、鼻痒评分呈正相关。结论:血清白细胞介素含量且具有检测方便、客观性强的优势,能够便捷、准确、客观的反应变应性鼻炎患者的整体病情,临床应用价值明确。Objective： To investigate the serum interleukin levels in allergic rhinitis patients and its clinical value. Methods. Allergic rhinitis patients admitted to our hospital were enrolled as observation group and healthy people underwent physical examination were enrolled as control group. Then serum IL- 4, IL-5, IL-17, IL-33 content and airway function were detected, clinical symptom score were evaluated. Results.（1） IL-4, IL-5, IL-17, IL-33 contents of observation group were higher than those of control group; （2） PEF, FEV1/FVC % of observation group were lower than those of control group, nasal itching, nasal congestion, runny nose, sneezing score of observation group were higher than those of control group; （3） IL-4, IL-5, IL-17, IL-33 contents were negatively correlated with PEF, FEV1/FVC and positively correlated with nasal itching, nasal congestion, runny nose, sneezing score. Conclusion： Serum interleukin content shows clear clinical application value since it is a convenient, quick, and objective detection which can reflect general status of allergic rhinitis patients.

关 键 词：变应性鼻炎 白细胞介素 气道功能 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]