十一酸睾酮改善维持性血液透析男性患者生存质量的随机对照试验  

Testosterone Undecanoate for Improving Quality of Life of Male Patients Undergoing Continuous Hemodialysis: A Randomized Controlled Trial

作　　者：潘松球[1] 黎琦[1] 吴曙粤[1] 蒙陆丹[1] 曾巧[1] 张劲[1] 钟庆荣[1] 周瑞玲[1] 李江宁[1] 

机构地区：[1]广西南宁市第一人民医院肾内科,南宁市530022

出　　处：《广西医学》2014年第3期303-305,共3页Guangxi Medical Journal

基　　金：广西南宁市科学研究与技术开发计划项目(ZC200803C)

摘　　要：目的观察十一酸睾酮(TU)在改善维持性血液透析男性患者生存质量方面的作用及其安全性和耐受性。方法将血清睾酮低于9.02 nmol/L的维持性血液透析男性患者70例,随机分为观察组和对照组,每组35例。观察组除了常规血液透析外加用口服TU 80 mg/早、40 mg/晚,2周后改为40 mg早晚各1次,疗程6个月;而对照组仅常规血液透析。用生存质量测定量表(WHOQOL-100)评价生存质量,用国际勃起功能指数-5(IIEF-5)评价性功能,同时检测血红蛋白(Hb)、血清前蛋白(PA)、血清白蛋白(AlB)、血清转铁蛋白(TRF)、血肌酐(Scr)及血清睾酮水平(T)变化。结果 (1)口服TU 6个月后,观察组Hb、PA、AlB、TRF及T值明显高于对照组(P<0.05),Scr、PSA值差异无统计学意义(P>0.05)。(2)治疗后观察组生理领域、独立性领域及总的生存质量评分高于对照组(P<0.05),余因子分差异无统计学意义(P>0.05)。(3)观察组经TU治疗后IIEF评分优于对照组。(4)排尿困难、下肢水肿等不良反应两组比较,差异均无统计学意义(P>0.05)。结论 TU能明显改善维持性血液透析男性患者生存质量、性功能、贫血及营养状况,具有良好的安全性和耐受性。Objective To study the effectiveness,safety and tolerance of testosterone undecanoate（TU） in improving quality of life （ QOL） of male patients undergoing continuous hemodialysis .Methods Seventy male patients undergoing continuous hemodialysis whose serum total testosterone （T） levels were lower than 9.02 nmol/L were randomly divided into observation group and control group ,with 35 cases in each group .The observation group was treated with routine hemodialysis and TU（80 mg/morning and 40 mg/night,and then 40 mg/morning and 40 mg/night after two weeks）,the treatment lasted for 6 months.The control group was treated with routine hemodialysis alone .The patients′QOL was assessed with WHOQOL-100 while their sexual function was assessed with the international index of erectile function （IIEF-5）. Haemoglobin（Hb）,prealbumin（PA）,albumin（ALB）,transferring（TRF）,serum creatinine（Scr）,serum testosterone（T） were measured.Results ①The levels of Hb,PA,ALB,TRF and T of observation group were significantly higher than those of control group 6 months after TU treatment （P〈0.05）,but the levels of Scr,PSA showed no significant difference between two groups（P〉0.05）.②QOL scores in physiology ,independence fields and total QOL scores of observation group were significantly higher than those of control group （P〈0.05）,but other QOL scores showed no significant difference between two groups（P〉0.05）.③IIEF scores of observation group were superior to those of control group （ P〈0 .05 ） .④There were no significant differences in adverse effects （ such as dysuria ,lower extremity edema and so on） between two groups （P 〉0.05）.Conclusion TU can improve QOL,sexual function,anemia and nutritional status of male patients undergoing continuous hemodialysis significantly ,with good safety and tolerance .

关 键 词：肾衰竭 血液透析 十一酸睾酮 生存质量 男性患者 

分 类 号：R459.5[医药卫生—治疗学]