某医院2012年药物变态反应147例分析  

Analysis of 147 cases of drug allergy in our hospital in 2012

作　　者：吴蔚[1] 

机构地区：[1]广西壮族自治区人民医院药剂科,南宁530021

出　　处：《中国临床新医学》2014年第3期228-231,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的了解该院2012年药物变态反应(DA)的发病及诊治情况。方法对该院2012年发生的147例DA进行回顾性分析。结果全身性反应79例(53.7%),其中过敏性休克6例;皮肤反应68例(46.3%)。导致DA的药物前三位是抗生素、中药注射剂、抗肿瘤药物。静脉给药途径发生率最高,发生快,症状重,口服及局部外用药发生率较低,发生慢,症状轻。经停药(或换药)、抗过敏、对症、激素治疗均缓解或好转,6例过敏性休克均治愈。结论应加强抗生素、中药注射剂、抗肿瘤药物等新药、中药的管理,密切关注患者的用药经过,及时发现DA及处理,确保患者用药安全。Objective To investigate the incidence and treatment of drug alletgy （DA） in our hospital in 2012 .Methods One hundred and forty-seven cases of DA in our hospital during 2012 were retrospectively analyzed . Results There were 79 cases of systemic reaction （53.7%） including 6 cases of allergic shock , 68 cases of skin re-action（46.3%） .The fist three drugs resulting in DA included antibiotics , antineoplastic drugs and traditional Chi-nese medicine injection .The DA was characterized by acute onset and severe symptoms;The DA incidence of intrave-nous medication was the highest .The DA incidence of oral and topical medication was lower ,the DA was character-ized by slower onset and milder symptoms .By stopping （ or changing ） drugs.anti-allergic therapy hormone , symp-tomatic treatment , the symptoms can be alleviated or disease condition got better;6 cases of allergic shock also were cured.Conclusion It is necessary to strengthen the management of traditional Chinese medicine injection agent , an-tibiotiotis and antineoplastic drugs , pay close attention to the medication process of patients , timely detect and treat DA,in order to ensure the safety of patients in medication process .

关 键 词：药物变态反应 临床表现 诊断 治疗 

分 类 号：R969[医药卫生—药理学]