真菌Peroxins蛋白的性质和功能  

Charastics of fungal peroxins

作　　者：苏浩[1] 赵勇[1] 杨攀[1] 黄成翔[1] 张克勤[1] 杨金奎[1] 

机构地区：[1]云南大学生物资源保护与利用国家重点实验室培育基地,云南昆明650091

出　　处：《微生物学通报》2014年第4期725-733,共9页Microbiology China

基　　金：国家自然科学基金项目(No.30960229;31272093);中国科学院西部之光人才培养计划项目;云南省中青年学术和技术带头人后备人才项目(No.2009CI052)

摘　　要：过氧化物酶体(Peroxisome)是普遍存在于各种真核细胞中的一类单层膜的细胞器,其内所含的各种酶在细胞的生理代谢过程中发挥着重要作用。目前,在真菌中已报道30多种参与过氧化物酶体的组装、分化和遗传调控的蛋白,这些蛋白被称为Peroxins(编码基因为PEX,编码的蛋白为Pexp)。Peroxins还参与真菌的乙醛酸循环和脂肪酸代谢,并与真菌的致病性密切相关。近年来,随着基因组测序技术的发展和新实验技术手段的应用,Peroxins的功能在日益增多的真菌中被鉴定。本文对真菌中已报道Peroxins的种类及它们在不同真菌中的分布进行总结,对Peroxins的性质和功能进行评述。Peroxisome is an organelle with single membrane in various eukaryotic cells, and contains various enzymes essential for multiple physiological and metabolic processes in organisms. At present, more than 30 proteins that control peroxisome assembly, division, and inheritance are identified from fungi, named peroxins （encoded by PEX genes）. Peroxins are also involved in glyoxylate cycle and in fatty acid metabolism, and related closely with the pathogenicity of fungi. Recently, peroxins have been identified from increasing number of fungi with the development of genome sequencing technology, as well as the application of novel experimental technology. In this review, we summarized the category and distribution of peroxins, and discussed the properties and functions ofperoxins in fungi.

关 键 词：真菌 过氧化物酶体 Peroxins 性质 功能 

分 类 号：Q936[生物学—微生物学]