小鼠卵巢原代表面上皮细胞转化模型的研究进展  

Evaluation on research progress in the transition model of primary ovarian surface epithelial cells

作　　者：胡志勇[1] 张鹤美[2] 王萍[2] 李冰燕[2] 

机构地区：[1]浙江省丽水市疾病预防控制中心,浙江丽水323000 [2]苏州大学医学部公共卫生学院卫生毒理教研室,江苏省放射医学与防护重点实验室,江苏苏州215000

出　　处：《现代预防医学》2014年第8期1452-1456,共5页Modern Preventive Medicine

基　　金：国家自然科学基金项目(81072286);国家自然科学基金项目(30972467);江苏省高校自然科学基础研究项目(07KJB330108)

摘　　要：卵巢癌是致死率最高的一种妇科肿瘤,其中上皮-间质细胞癌占90%,但由于目前缺乏早期的诊断指标及预防策略,一直呈现低发现率高死亡率的特征。近年来,有关卵巢原代上皮(Ovarian Surface Epithelial,OSE)细胞的研究取得了较大的进展,这对认识卵巢癌发生、发展有重要作用。有证据显示,卵巢原代表面上皮细胞自发转化过程中发生的细胞和分子水平的变化对卵巢癌早期和晚期识别具有重要意义。本文就小鼠卵巢原代上皮细胞(Mouse Ovarian Surface Epithelial Cells,MOSEC)模型的建立、转化阶段、可能参与的蛋白及信号通路的变化作一系统的综述,为卵巢癌的预防及治疗策略提供一些新的思路。Ovarian cancer is a kind of gynecological tumor with the highest mortality, and epithelial ＆ interstitial cell carcinoma accounts for 90% of ovarian cancer. Because the diagnostic criteria and disease prevention strategies are inadequate, ovarian cancer has the characteristics of low detection probability and high mortality. The studies of primary ovarian surface epithelial cells have made great progress in the past few years. The primary ovarian surface epithelial cells have been suggested to play a role in the oc- currence and development of ovarian cancer. Some evidences indicate that the spontaneous transformation of primary ovarian sur- face epithelial cells in vitro is significant in identifying the prophase and advanced stage of ovarian cancer on cellular and molecular level.

关 键 词：卵巢癌 原代上皮细胞 小鼠 综述 

分 类 号：R319[医药卫生—基础医学]