尿胱抑素C和白细胞介素-18诊断危重新生儿急性肾损伤的临床研究  

Clinical study on urine cystatin C and interleukin- 18 in diagnosis of acute kidney injury in critically ill neonates

作　　者：李琳琳[1] 

机构地区：[1]内蒙古医科大学附属医院儿科,内蒙古呼和浩特010059

出　　处：《中国妇幼保健》2014年第12期1857-1859,共3页Maternal and Child Health Care of China

摘　　要：目的:研究尿中胱抑素C(uCys C)和尿中白细胞介素-18(uIL-18)对诊断危重新生儿急性肾损伤(AKI)的价值。方法:选择急性肾损伤(AKI)新生儿及正常新生儿为研究对象,每天收集尿标本,持续7天,应用颗粒增强免疫比浊法测定尿液标本中的CysC,ELISA法检测尿液标本中的IL-18水平。根据测量结果分为4组:A组(uCysC>1.3 g/ml)、B组:(uIL-18>95 pg/ml),C组(uCysC>1.3 g/ml和uIL-18>95 pg/ml),D组为正常组(尿CysC≤1.3 g/ml和尿IL-18≤95 pg/ml)。结果:从开始观察7天内各组AKI患病率不完全相同(χ2=68.259,P<0.001),7天内A、B、C 3组AKI的罹患率均高于D组(P<0.05)。结论:uCys C和uIL-18在诊断危重AKI新生儿的临床研究具有早期诊断作用。Objective： To research the values of urine cystatin C （ uCys C） and interleukin - 18 （ulL - 18 ） in diagnosis of acute kidney injury （AKI） in critically ill neonates. Methods： The neonates with AKI and normal neonates were selected as study objects; their urine specimens were obtained every day for 7 days ; PETIA was used to detect the levels of CysC in urine specimens ; ELISA was used to de- tect the levels of ulL - 18 in urine specimens. The neonates were divided into four groups ： A group （ uCysC 〉 1.3 g/ml）, B group （ ulL - 18 〉 95 pg/ml）, C group （ uCysC 〉 1.3 g/ml and ulL - 18 〉 95 pg/ml） and D group （ uCysC ≤ 1.3 g/ml and ulL - 18 ≤95 pg/ml） . Re- suits： There was statistically significant difference in the prevalence rate of AKI within 7 days among the four groups （X2 = 68. 259, P 〈 0. 001 ） ; the prevalence rates of AKI in A group, B group and C group were statistically significantly higher than that in D group （P 〈 0. 05） . Conclusion： uCys C and ulL- 18 can early diagnose AKI in critically ill neonates.

关 键 词：急性肾损伤 尿胱抑素C 尿白细胞介素-18 新生儿 

分 类 号：R722.1[医药卫生—儿科]