不同剂量瑞舒伐他汀对急性心肌梗死患者急诊PCI血浆sOX40L的影响  

Effect of different doses rosuvastatin on plasma level of sOX40L in acute myocardial infarction patients undergoing primary PCI

作　　者：王慧[1] 徐萍[1] 王万粮[1] 卢荣荣[1] 

机构地区：[1]沈阳医学院附属第二医院心内科,沈阳110002

出　　处：《中国当代医药》2014年第11期46-48,共3页China Modern Medicine

基　　金：沈阳医学院科技基金项目(20122037)

摘　　要：目的探讨不同剂量瑞舒伐他汀对急性心肌梗死(AMI)患者急诊PCI血浆sOX40L的影响。方法将入选的行急诊PCI的66例AMI患者随机分为A组(急诊PCI术前12 h内给予瑞舒伐他汀20 mg,术后20 mg口服,每晚1次,口服7 d)和B组(术前口服安慰剂,PCI术后瑞舒伐他汀10 mg,每晚1次,口服7 d)。观察术前及术后不同时间点sOX40L和hs-CRP水平的变化。结果两组间PCI术前sOX40L和hs-CRP水平比较,差异无统计学意义(P>0.05),hs-CRP分别为(18.40±2.64)、(17.95±2.72)mg/L,sOX40L分别为(30.24±18.14)、(30.83±18.68)pg/ml;PCI术后24 h两组患者sOX40L和hs-CRP的水平均较术前均明显升高(P<0.05),hs-CRP分别为(27.64±2.75)、(28.18±2.91)mg/L,sOX40L分别为(38.71±17.36)、(41.93±17.71)pg/ml;PCI术后48 h及7 d,与B组比较,A组的sOX40L和hs-CRP水平明显降低(P<0.05)。结论 PCI可增加sOX40L、hs-CRP的表达;瑞舒伐他汀可有效减轻AMI患者急诊PCI术后炎症反应,且高剂量效果更优。Objective To investigate the effect of different doses rosuvastatin on plasma level of sOX40L and myocardial damage in acute myocardial infarction patients undergoing primary PCI. Methods 66 cases of acute myocardial in- farction patients underwent primary PCI were enrolled.These patients were divided into two groups：A group（rosuvastatin 20 mg for pre-operation 12 h and rosuvastatin 20 mg, 1 times a night,for 7 days in post-operation）,B group（placebo for pre-operation and rosuvastatin 10 mg,1 times a night,for 7 days in post-operation）.The difference plasma level of sOX40L and hs-CRP were examined in designed time points between the two groups were observed. Results The dif- ferences of sOX40L and hs-CRP between the two groups were not obviously different before PCI （P〉0.05）,which with the levels of hs-CRP was（18.40±2.64）,（17.95±2.72）mg/L,the levels of sOX40L was（30.24±18.14）,（30.83±18.68）pg/ml.Be- tween two groups,the level of sOX40L and hs-CRP were increased more distinctly at 24 hours after PCI as compared with before PCI（P〈0.05）,which with the levels of hs-CRP was（27.64±2.75）,（28.18±2.91）mg/L,the levels of sOX40L was （38.71±17.36）,（41.93±17.71）pg/ml.In the post-operation for 48 hours and 1 week,the level of sOX40L and hs-CRP were decreased more significantly in A group than those of B group （P〈0.05）. Conclusion PCI can increases the level of sOX40L and hs-CRP.For acute myocardial infarction patients undergoing primary PCI,treatments with high-dose rosu- vastatin can decline inflammatory reaction,improve the stability of vulnerable plaque.

关 键 词：急性心肌梗死 瑞舒伐他汀 

分 类 号：R542.2[医药卫生—心血管疾病]