内皮间充质转化的研究进展  

The research progress of endothelial-to-mesenchymal transition

作　　者：闫飞[1] 侯新国[1] 陈丽[1] 

机构地区：[1]山东大学齐鲁医院内分泌科,济南250012

出　　处：《中国糖尿病杂志》2014年第4期382-384,共3页Chinese Journal of Diabetes

摘　　要：内皮间充质转化(EndMT)即内皮细胞在促成纤维刺激下可获得成纤维细胞样表型。EndMT不仅参与人体心脏正常发育,还参与诸多疾病的发生发展。本文就近年来EndMT发生机制及其相关疾病研究进展作一综述,以期为临床相关疾病治疗提供新靶点。Endothelial cells, under pressure of pro-fibrotic stimuli, will acquire a fibroblast-like phenotyp~ This type of cellular transition is called endothelial-to-mesenchymal transition （EndMT）. EndMT not only participates the growth of the heart but also contributes to many diseases. This review will focus on the recent advance of pathogenesis of EndMT and may help to provide new targets for the treatment of many diseases.

关 键 词：内皮间充质转化 肿瘤相关成纤维细胞 糖尿病心肌病 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]