伏隔核的M_1和M_4型毒蕈碱乙酰胆碱受体参与吗啡奖赏记忆的表达  

THE M_1 AND M_4 MUSCARINIC ACETYLCHOLONERGIC RECEPTORS IN NUCLEUS ACCUMBENS PLAY ROLES IN THE EXPRESSION OF MORPHINE- INDUCED CONDITIONED PLACE PREFERENCE

作　　者：李慧[1] 李鹏[2] 陈磊[1] 黄新洁[1] 翟海峰[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100191 [2]北京中医药大学中药学院,北京100102

出　　处：《中国药物依赖性杂志》2014年第2期93-98,共6页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金(30873051;81271473);北京市自然科学基金(7112087)

摘　　要：目的獉獉:探究M1受体的阻断剂及M4受体的激动剂对吗啡诱导的条件性位置偏爱表达的影响。方法獉獉:采用大鼠吗啡条件性位置偏爱(CPP)模型及脑部核团微注射的方法。结果獉獉:与生理盐水对照组相比,M1受体拮抗剂Pirenzepine可以增强吗啡CPP的表达,M4受体激动剂LY2033298也可以增强吗啡CPP的表达。结论獉獉:伏隔核的M1和M4型受体参与吗啡奖赏记忆的表达。Objective：To explore the roles of M1 and M4 muscarinic acetylcholinergic receptors in the expression of morphine - induced conditioned place preference （CPP）, Methods： The model of morphine -induced CPP in rat and the microinjections into nucleus aecurnbens were adopted. Results：It was found that the antagonist of M1 receptor （ Pirenzepine ） enhanced the expression of morphine - induced CPP, and that the agonist of M4 receptor （LY2033298） also amplified the expression of morphine - induced CPP. Conclusion： The M1 and M4 receptors in nucleus accumbens play roles in the modulation of morphine reward memory.

关 键 词：毒蕈碱乙酰胆碱受体 吗啡 条件性位置偏爱 

分 类 号：R962[医药卫生—药理学]