刺五加对24h持续黑暗环境所致果蝇睡眠节律改变的干预作用  

THE EFFECT OF CIWUJIA ON THE SLEEP RHYTHM OF DROSOPHILA MELANOGASTER UNDER 24 HOUR CONSTANT DARKNESS

作　　者：卞宏生[1] 金阳[1] 黄莉莉[1] 李廷利[1] 

机构地区：[1]黑龙江中医药大学,哈尔滨150040

出　　处：《中国药物依赖性杂志》2014年第2期103-107,共5页Chinese Journal of Drug Dependence

基　　金：教育部春晖计划(Z2007-1-15003);国家自然科学基金青年基金(30801528)

摘　　要：目的獉獉:探讨刺五加对24 h持续黑暗环境下果蝇睡眠节律改变的干预作用。方法獉獉:以果蝇为观察对象,分空白、模型和模型给药组,模型给药组给予浓度为0.25%、1%、4%的刺五加,以睡眠时间和睡眠-觉醒节律为考察指标,用DAMS 24h监测,考察刺五加对果蝇的干预。结果獉獉:刺五加能增加果蝇连续活动时间,减少片段化睡眠,影响睡眠节律,0.25%组对雌果蝇作用明显(P<0.01);1%组对雄果蝇作用明显(P<0.05)。结论獉獉:刺五加能改善24 h持续黑暗环境下果蝇睡眠节律。Objective：The purpose of this study is to investigate the effect of a Chinese medicine - CIWUJIA （CWJ） on the sleep rhythm of 7 - day - old drosophilas under 24 h constant darkness environment. Methods： Seven -day -old drosophilas were picked out and divided into blank control group, model group and medication administration group with three doses. Medication administration group are given different concentrations of 0. 25, 1 and 4 percent of CWJ. DAMS was used to explore the dose - effect relationship of CWJ on the sleep duration and sleep rhythm after 24h continuous monitoring in the same light intensity. Results： CWJ partly increased the number of drosophila＇ s activity, reduced the fragments of drosophila＇ s sleep time and changed the sleep rhythm, especially in 0.25 percent of CWJ in female drosophilas （ P 〈 0. 01 ）, and 1 percent of CWJ changed male drosophilas greatly （ P 〈 0. 05）. Conclusion： CWJ can improve drosophila＇ s sleep rhythm in 24h constant darkness environment.

关 键 词：果蝇 刺五加 睡眠节律 果蝇活动监测系统 

分 类 号：R965.2[医药卫生—药理学]