帕金森病模型大鼠内侧前额叶皮层锥体神经元NMDA受体敏感性下降  

NMDA receptor sensitivity decrease of the pyramidal neurons in mPFC of PD rat

作　　者：王爽[1] 高捷[2] 苏兴利[1] 郭玉芳[1] 霍健[1] 王湘[1] 

机构地区：[1]西安医学院病理生理学教研室,陕西西安710021 [2]西安医学院教务处,陕西西安710021

出　　处：《中国现代医学杂志》2014年第1期1-4,共4页China Journal of Modern Medicine

基　　金：陕西省科技厅青年基金资助(No:2011JQ4005);陕西省科技厅基金资助(No:2012KJXX-43);陕西省教育厅基金资助(No:2013JK0761)

摘　　要：目的研究6-羟多巴胺(6-OHDA)损毁大鼠黑质致密部(SNc)后内侧前额叶皮层(mPFC)中锥体神经元NMDA受体敏感性的变化。方法应用在体细胞外电生理学记录的方法观察6-OHDA损毁大鼠SNc后,全身应用NMDA受体阻滞剂MK-801后锥体神经元放电频率的变化。结果全身应用NMDA受体阻滞剂MK-801后,PD组大鼠锥体神经元放电频率无明显变化(P>0.05)。结论帕金森病模型大鼠内侧前额叶皮层锥体神经元的NMDA受体敏感性下调。[ Objective ] To study the neuronal activity of pyramidal neurons and the change of NMDA receptor sensitivity in mPFC of PD rat. [Methods] The change of the spontaneous firing of pyramidal neurons in mPFC after lesioned by 6-OHDA was observed by extracellular recording in vivo. [Result] In PD rats, the firing rate of pyrami- dal neurons in mPFC did not change when MK-801 was treated compared with baseline. [ Conclusion] NMDA re- ceptor sensitivity decreased in mPFC of PD rat.

关 键 词：帕金森病 内侧前额叶皮层 NMDA受体 锥体神经元 电生理学 

分 类 号：R338.2[医药卫生—人体生理学]