Castleman病13例临床病理分析  

A clinicopathological study of castleman disease

作　　者：安慧敏[1] 郭德超[2] 潘升华[1] 吴文珍[1] 夏康[1] 廖谦和[1] 

机构地区：[1]浙江省温州医学院附属第三医院病理科,浙江省温州市325200 [2]浙江省温州医学院附属第三医院普外科,浙江省温州市325200

出　　处：《中华全科医学》2014年第5期711-712,共2页Chinese Journal of General Practice

摘　　要：目的探讨Castleman病的临床病理学特点,以提高对该病的认识。方法回顾性分析2004—2012年温州医学院附属第三医院收治的13例Castleman病的临床病理资料,并结合文献复习。结果 13例Castleman病的临床分型:局限型12例,主要表现为局部淋巴结大;多中心型1例,主要表现为全身多部位淋巴结大伴脾大、贫血、清蛋白降低等。病理分型:透明血管型8例(8/13,61.5%),浆细胞型2例(2/13,15.4%),混合型3例(3/13,23.1%)。全部Castleman病均行手术完整切除,患者术后情况良好。结论 Castleman病是一种少见的、病因不明的淋巴组织增生性疾病,术前临床诊断有一定困难。本病治疗以外科手术为主,多中心型患者术后采用化疗等辅助治疗,可缓解症状。Objective To investigate the clinicopathological features of Castleman disease,and improve the diagnosis and treatment of this disease. Methods The clinical and pathologic data of 12 patients with Castleman disease in our hospital from 2004 to 2012 were retrospectively analyzed with a review of literature. Results The clinical types ： there were 12 ca- ses of localized Castleman＇ s disease（ Unicentric Castleman＇ s disease） with the main manifestation of hyperplasia of re- gional lymph node ; 1 case of Muhicentric Castleman＇ s disease with the main manifestations of widespread lymphadenopa- thy with hepatosplenomegaly, anemia and lower levels of albumin, and so on. The pathological types ： hyaline-vascular type （ 8/13,61.5% ） , plasma-cell type （ 2/13,15.4% ） , and mixed type （ 3/13,23.1% ）. All the patients survived after the complete resection of the mass. Conclusion Castleman disease is a rare disease of unknown cause with lymphoprolifera- tive disorders. It is not easy to diagnose before the operation. The treatment of Castleman disease should aim at surgical treatment. For the multicentric type ,surgical operation combined chemotherapy can relieve symptoms.

关 键 词：CASTLEMAN病 临床病理学 治疗 

分 类 号：R551.2[医药卫生—血液循环系统疾病] R343.31[医药卫生—内科学]