孕中期1044例Down's综合征血清学筛查结果分析  

Analysis of Serological Screening of Down's Syndrome in 1044 Mid-Pregnant Women

作　　者：胡义忠[1] 吴芬[1] 苏静[1] 叶助芝 

机构地区：[1]池州市人民医院检验科,安徽池州247000

出　　处：《长江大学学报（自科版）（下旬）》2014年第3期12-14,共3页Journal of Yangtze University

基　　金：池州市2011年医疗卫生研究课题

摘　　要：目的：探讨孕中期母体血清标志物筛查Down’s综合征（DS）的临床应用价值。方法：应用化学发光免疫法测定孕中期（14-21周）孕妇1044例血清中甲胎蛋白（AFP）和游离8绒毛膜促性腺激素（free-β-HCG）的浓度，应用汉唐生物工程软件分析Down’s综合征的风险率，风险切割值为1／275，对高风险孕妇进行羊水细胞染色体核型分析确诊。结果：孕妇血清中AFP浓度随孕周的增加而增加，free-β-HCG的浓度随孕周的增加而减少。1044例孕妇中，共筛查出DS高危孕妇39例，临界1例，阳性率3．83％，其中17例接受羊膜腔穿刺，确诊胎儿Down’s综合征l例。≥35岁孕妇组高危率明显高于35岁以下的孕妇组（P〈O．01）。结论：孕中期产前筛查DS是预测胎儿异常和先天缺陷的重要措施。objective:To explore clinical applications of the second trimester Maternal serum marker screening for Down's syndrome(DS).Methods:Chemiluminescent immunoassay was applied for determining concentrations of maternal serum alpha-fetoprotein(AFP)and free beta HCG(free-β-HCG)in 1044cases of the second-trimester(14-21week).Han Tang bio-engineering software made in Weifang,Shandong was used to analyze risks of Down's syndrome,and the risk value of cutting was one-two hundred and seventy fifth.The high-risk pregnant women were diagnosed by analyzing chromosome karyotype of amniotic fluid cells.Results:Maternal serum AFP concentration increased with increase in gestational weeks,while free-β-HCG concentrations decreased with increase in gestational age.39cases of DS high-risk in 1044pregnant women were detected by screening with 1critical case and the positive rate was 3.83%.Among 39cases,17were treated with amniocentesis with 1case confirmed.The risk rate of the pregnant women above 35years old was significantly higher than the other groups of pregnant women under 35years old(P<0.01).Conclusion:The second-trimester prenatal screening for DS is an effective measure to detect fetal abnormalities and birth defects.

关 键 词：Down’s综合征 产前筛查 甲胎蛋白 游离β绒毛膜促性腺激素 

分 类 号：R446.6[医药卫生—诊断学]