肥大细胞在宿主真菌感染免疫反应中的作用  

Roles of Mast Cells in Host Immune Responses against Fungal Infections

作　　者：王珊[1] 刘玲玲[1] 赵作涛[1] 

机构地区：[1]北京大学第一医院皮肤病与性病科,北京100034

出　　处：《中华临床免疫和变态反应杂志》2014年第1期63-69,共7页Chinese Journal of Allergy & Clinical Immunology

基　　金：国家自然基金青年基金(30800041)

摘　　要：肥大细胞除了在变态反应性疾病中发挥关键作用外,也是宿主针对病原感染固有免疫中重要的效应细胞。有关肥大细胞在病原感染中的作用机制已逐渐被揭示,如肥大细胞在细菌、病毒及寄生虫感染中的作用。然而,肥大细胞在真菌感染免疫反应(感染-变态反应)中的作用仍未明了。本文就近年有关肥大细胞在宿主对真菌感染免疫反应中的研究结果做一综述,包括肥大细胞分布与真菌感染、肥大细胞对真菌的识别、信号转导通路及释放炎症因子等方面分别阐释。In addition to the key role in the pathogenesis of allergic diseases, mast cells are also important effector cells in the host innate immune responses of pathogenic microorganism infections. Since the last decades, the role of mast cell in the pathogenesis of pathogenic microorganism infections such as parasites, bacteria and virus infections had been revealed, but its role in fungal infection （infection-inflammation/allergy） is still unclear. The current studies on the role of mast cell in the host immune responses against fungal infections were summarized in this review, including the recognition of pathogens, the signal transduction pathway and the mediators releasing.

关 键 词：肥大细胞 真菌感染 固有免疫 变态反应 

分 类 号：R593.1[医药卫生—内科学]