正电子发射计算机断层显像计算机断层扫描在系统性血管炎诊断及病情评估中的应用  

Value of Positron Emission TomographyComputed Tomography in the Diagnosis and Disease Activity Assessment of Systemic Vasculitis

作　　者：张炎[1] 沈敏[2] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院风湿免疫科风湿免疫病学教育部重点实验室,北京100730

出　　处：《中华临床免疫和变态反应杂志》2014年第1期70-75,共6页Chinese Journal of Allergy & Clinical Immunology

基　　金：中华医学会临床医学科研专项资金(12040760376);北京协和医院青年科研基金(2010103)

摘　　要：系统性血管炎临床表现复杂,对于缺乏特征性表现者的诊断和病情严重程度评估,临床医生面临巨大的挑战。现有影像学检查手段对系统性血管炎的早期、活动性病变敏感性较低。正电子发射计算机断层显像与计算机断层扫描技术(positron emission tomographycomputed tomography,PETCT)对系统性血管炎中巨细胞动脉炎风湿性多肌痛、大动脉炎等大血管炎的诊断具有比较高的敏感新和特异性,特别是在疾病的早期和活动期,而对于中小血管受累的系统性血管炎并无太大帮助。通过PETCT可以全面了解系统性血管炎的解剖和功能定位,弥补其他影像学检查的不足。应注意在PETCT上系统性血管炎与其他血管疾病的鉴别。PETCT检查在系统性血管炎疗效评估中的作用尚有待进一步研究。Systemic vasculitis is a group of diseases with complex manifestations. The diagnose and disease activities evaluation is very difficult, especially in those without typical clinical signs. Positron emission tomography/computed tomography could be used for early diagnosis of active large vessel vasculitis such as giant cell arteritis/polymyalgia rheumatica and Takayasu arteritis, with a high sensitivity and specificity, and is more reliable than other imaging methods. It is also important that differential diagnosis should be performed for other vascular diseases. More studies are needed to assess the application of PET/CT in disease activity evaluation of systemic vasculitis.

关 键 词：系统性血管炎 正电子发射计算机断层显像 巨细胞动脉炎 风湿性多肌痛 大动脉炎 

分 类 号：R593.2[医药卫生—内科学]