仙茅多糖对小鼠S_(180)实体瘤的顺铂增敏作用及其机制  

Efficacy enhancing effect and mechanisms of Curculigo orchioides polysaccharide on S_(180) tumor-bearing mice treated by Cisplatin

作　　者：姚佳[1] 彭梅[1] 肖雄[1] 唐健波[1] 胡江义 杨娟[1] 

机构地区：[1]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002 [2]贵阳医学院,贵州贵阳550004

出　　处：《华西药学杂志》2014年第2期132-134,共3页West China Journal of Pharmaceutical Sciences

基　　金：973计划前期研究专项(2012CB722601);贵州省社会发展科技攻关计划项目[黔科合SY字(2011)3022号]

摘　　要：目的探讨仙茅多糖对顺铂的增效减毒作用及其机制。方法建立小鼠S180实体瘤模型,连续给药10 d,测定小鼠的瘤重、体质量、白细胞、红细胞、胸腺指数、脾脏指数以及小鼠血清和肾脏的多项生化指标。结果仙茅多糖能对抗顺铂引起的白细胞减少、胸腺萎缩、脾脏肿大(P<0.05或P<0.01),同时减少血清中尿素氮、肌酐的含量(P<0.05或P<0.01),增加血清和肾脏总超氧化物歧化酶活力(P<0.05或P<0.01),降低血清和肾脏中的丙二醛含量(P<0.05或P<0.01)。结论仙茅多糖对顺铂具有一定的增效减毒作用,机制可能与其能调节机体免疫力,抑制脂质过氧化有关。OBJECTIVE To study the efficacy enhancing, toxicity reducing effect and mechanisms of Curculigo orchioides polysac- charide （COP） on S180 tumor - bearing mice treated by Cisplatin. METHODS A model of S180 solid tumor was established. After suc- cessive administration of 10 d, the tumor＇ s weight, body mass, blood cells, thymus index and spleen index were measured and multiple biochemical indexes in the serum and kidney were analysed. RESULTS COP could inhibit the leukopenia, thymic atrophy, spleen enlargement induced by Cisplatin （P 〈0.05 ,P 〈0.01 ）. At the same time,COP could significantly reduce the levels of BUN and SCr in serum （P 〈 0. 05, P 〈 0. 01 ） , increase the activity of SOD and decrease the content of MDA in the serum and kidney. CONCLUSION COP can enhance the effects of antitumor effects and reduce toxicity of Cisplatin. The mechanism may be related to adjusting the body immunity and suppressing the generation of lipid peroxides.

关 键 词：仙茅 多糖 顺铂 增效 减毒 机制 

分 类 号：R96[医药卫生—药理学]