落叶松中花旗松素对酪氨酸酶的抑制作用  

Inhibitory effect of taxifolin in Larix olgensis on tyrosinase

作　　者：付警辉[1] 柴婧[1] 韩佳彤[1] 刘文丛[1] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118

出　　处：《日用化学工业》2014年第4期218-221,共4页China Surfactant Detergent & Cosmetics

摘　　要：以L-多巴为底物，熊果苷和2，6-二叔丁基-4-甲基苯酚（BHT）为阳性对照，研究了长白落叶松花旗松素对酪氨酸酶的抑制作用，并与兴安落叶松花旗松素进行了对比。结果表明，质量浓度在0．001～0．01g·L^-1时，长白落叶松花旗松素对酪氨酸酶的抑制作用高于兴安落叶松花旗松素。长白落叶松花旗松素，低质量浓度时，纯度越高，对酪氨酸酶的抑制作用越强；高质量浓度时，纯度越高，抑制作用越弱。长白落叶松花旗松素对酪氨酸酶表现为竞争性抑制，抑制常数K=0．017。Taking L - DOPA as substrate, arbutin and BHT as positive controls, the inhibitory effect on tyrosinase of the taxifolin in Larix olgensis was studied and compared with that in Larix g melini. Results showed that,when the mass concentration of taxifolin is 0. 001 -0. 01 g ·L^-1, the inhibitory effect of taxifolin in Larix olgensis is higher than that in Larix gmelini on tyrosinase. For Larix olgensis, under low mass concentration range condition, the higher purity of taxifolin, the stronger inhibitory effect on tyrosinase ; while under high mass concentration range condition, the higher purity of taxifolin, the weaker inhibitory effect on tyrosinase. Taxifolin in Larix olgensis shows competitive inhibition mechanism for tyrosinase with an inhibition constant Kj of 0. 017.

关 键 词：化妆品 花旗松素 酪氨酸酶 长白落叶松 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]