异位胰腺误诊为胃肠间质瘤的临床分析  

Retrospective clinical analysis of heterotopic pancreas misdiagnosed as gastrointestinal stromal tumors

作　　者：屠霖[1] 徐佳[1] 曹晖[1] 

机构地区：[1]上海交通大学医学院附属仁济医院普通外科,200127

出　　处：《中华胃肠外科杂志》2014年第4期348-351,共4页Chinese Journal of Gastrointestinal Surgery

基　　金：上海市科委重点项目课题（11411950800）;上海市科委生药课题项目课题（13411950902）;上海市科委学科带头人课题（13XD1402500）

摘　　要：目的提高对异位胰腺与胃肠问质瘤的鉴别诊断水平。方法回顾性分析2007年1月至2013年6月于上海交通大学医学院附属仁济医院收治的14例术前诊断为胃肠间质瘤而术后病理证实为异位胰腺组织患者的临床资料及随访资料。结果本组病例男9例，女5例，年龄26，69岁。其中8例有上腹隐痛不适症状，2例为肠梗阻表现，4例为体检偶然发现。12例术前影像学检查及内镜检查均提示胃肠间质瘤。所有患者均行手术治疗，其中11例病变发生于胃，l例发生于十二指肠，2例发生于空肠；术后病理证实均为异位胰腺，其中10例以胰腺腺泡和胰腺导管混合存在为主要成分，同时含有平滑肌组织以及少量胃黏膜组织；3例以胰腺腺泡为主；1例以胰腺导管及平滑肌为主。随访时间为（26．5±5．1）月，均无复发和死亡者。结论异位胰腺缺乏特征性的临床表现和有效的术前辅助检查手段，易与胃肠间质瘤混淆。手术切除是治愈异位胰腺的唯一有效手段，而术后病理是鉴别两种疾病最可靠的诊断方法。Objective To improve the differential diagnosis and treatment between heterotopic pancreas and gastrointestinal stromal tumor. Method Clinical and follow-up data of 14 cases who were diagnosed preoperatively as gastrointestinal stromal tumor whereas were confirmed as heterotopie pancreas in the gastrointestinal tract by postoperative pathological results in Renji Hospital from January 2007 to June 2013 were analyzed retrospectively. Result There were 9 males and 5 females, aged ranged from 26 to 69 years old. Eight patients had upper abdominal pain, 2 presented with intestinal obstruction, and 4 were incidentally found on routine health check-up. The lesions located at the stomach in 11 cases, at the duodenum in 1 case, and at the jejunum in 2 cases. All the patients underwent operation. Postoperative pathology confirmed the diagnosis of heterotopic pancreas. Among these lesions, 10 cases presented with co-existence of pancreatic acinus and duct as main component with smooth muscle and few gastric mucosa tissues, 3 cases was mainly the pancreatic acinus and 1 case mainly the pancreatic duct and smooth muscle. Conclusions Heterotopic pancreas may be misrocognized at gastrointestinal stromal tumors due to non-specific clinical manifestations and effective examination methods. Surgical procedure is the only one and the most effective treatment. Postoperative pathology examination is the most difinitive for differential diagnosis.

关 键 词：胃肠间质瘤 异位胰腺 鉴别诊断 

分 类 号：R657.53[医药卫生—外科学]