视觉系统中钙库操纵钙内流通路的研究进展  

Research advances in store operated Ca^(2+) entry channel in vision system

作　　者：杜宇翔[1] 郭大东[2] 毕宏生[2] 

机构地区：[1]山东中医药大学,山东省济南市250014 [2]山东中医药大学眼科研究所,山东省高校中西医结合眼病防治技术重点实验室,山东省济南市250002

出　　处：《眼科新进展》2014年第4期389-393,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81072961);山东省自然科学基金资助(编号:ZR2010HM032)~~

摘　　要：钙库操纵的钙通道(store operated Ca2+channel,SOCC)和钙库操纵的钙内流(store-operated calcium entry,SOCE)普遍存在于细胞之中,是非兴奋细胞主要的钙内流方式,参与了机体众多的生理过程。许多眼科疾病的发生和发展与SOCE的异常密切相关。本文就近年来对SOCE途径的机制、STIM和Orai不同亚型的结构及在眼科疾病中的作用研究进行了回顾,以期为眼科疾病治疗提供新的思路。Store operated Ca2＋ channel （SOCC）and store-operated Ca2＋ entry （SOCE） are ubiquitously present in every cell type, which represent a predominant pathway of Ca2 ＋ entry into nonexcitable cells. Nevertheless, the phenomenon of aber- rant expressed SOCE has been observed in a growing number of eye diseases. In this paper, the pathways involved in SOCE, STIM （ stromal interaction molecule） and Oral （calcium release-activated calcium channel protein）in different subtypes are reviewed, further the structure and the role of SOCE in eye diseases are elucidated to provide new ideas approach for eye diseases.

关 键 词：钙库操纵的钙内流 基质相互作用因子 钙释放激活钙通道蛋白 眼科疾病 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学]