重组人粒细胞巨噬细胞集落刺激因子在压疮护理中的应用  

Application of Recombinant Human Granulocyte-macrophage Colony Stimulating Factorin Nursing of Pressure Ulcer

作　　者：张友群 杨柳 陶文俊 刘娟娟 

机构地区：[1]湖北省荆州市第三人民医院普外科

出　　处：《中国烧伤创疡杂志》2014年第2期125-129,共5页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的 探讨重组人粒细胞巨噬细胞集落刺激因子（rhGM-CSF）凝胶在Ⅱ～Ⅲ度压疮创面治疗和护理中的临床应用效果.方法 将85例（98处）Ⅱ～Ⅲ度压疮患者分为两组,试验组创面应用重组人粒细胞巨噬细胞集落刺激因子凝胶治疗,对照组创面应用磺胺嘧啶银（SD-Ag）霜治疗,观察、对比两组患者治疗效果、创面细菌培养及PUSH评分结果.结果 试验组平均愈合时间为16.75 d±l.22d,有效率为96.49％,对照组平均愈合时间为21.73 d±4.55 d,有效率为78.05％.换药14 d后,试验组患者创面PUSH评分为5.76±2.59,对照组为8.59±3.23,各项指标对比,差异均具有统计学意义（P＜0.01）.结论 重组人粒细胞巨噬细胞集落刺激因子凝胶能抑制Ⅱ～Ⅲ度压疮创面细菌繁殖,促进肉芽组织生成,显著缩短创面愈合时间.Objective To investigate the clinical efficacy of Recombinant Human Granulocyte-macrophage Colony StimulatingFaetor （rhGM-CSF） Gel in the wound treatment and care of II - III degree pressure ulcer. Methods 85 patients （98 wounds） with II - III degree pressure ulcer were divided into a treatment group and a control group. The treatment group was treated with rhGM-CFS Gel and the eontrol group was treated with SD-Ag Cream. The therapeutic effect, wound bacterial culture resuh and PUSH scoring were observed and eomparedbetween the two groups. Results In the treatment group, the average healing time was 16. 75 d ± 1.22 d and the effective rate was 96. 49%. while they were 21.73 d ± 4. 55 d and 78. 05% respeetively in the control group. After 14 d dressing change, the PUSH seoring was 5.76 ±2.59 （ in the treatment group） and 8.59- 3.23 （in the control group） respectively. Comparisonof the indicators between the two groupsshowed statistically significantdifferences （P 〈 0.01 ）. Conclusion RhGM-CSF Gel can inhibit bacteria reproduction, promote granulation tissue formation and shorten wound healing time significantly in the treatment of II - III degree pressure ulcer.

关 键 词：压疮 护理 粒细胞巨噬细胞集落刺激因子 SD-AG 疗效 对比 

分 类 号：R473.6[医药卫生—护理学]