抗淋巴细胞抗体与原发性干燥综合征临床相关性研究  

The relevance of anti-lymphocyte antibody with primary Sj（o）gren syndrome

作　　者：贾汝琳[1] 李晶[2] 何菁[1] 李春[1] 栗占国[1] 

机构地区：[1]北京大学人民医院风湿免疫科, 100044 [2] 中国科学院研究生院

出　　处：《中华风湿病学杂志》2014年第4期232-235,I0001,共5页Chinese Journal of Rheumatology

摘　　要：目的 了解抗淋巴细胞抗体（ALA）与pSS临床表现和免疫学指标的关系,并探讨ALA和淋巴细胞减少在pSS中的临床意义.方法 简单随机抽样（不重复）选取143例pSS患者以及45名健康体检者,利用间接免疫荧光法测定ALA水平.收集pSS患者临床及实验室资料,采用x2检验和t检验进行统计学分析.结果 ①在143例pSS患者中,ALA总阳性率为25.2％（36/143）,其中ALA在淋巴细胞减少组的阳性率43.9％（29/66）明显高于淋巴细胞正常组的6.5％（5/77）,2组比较差异有统计学意义（x2=27.496,P＜0.01）.②ALA阳性组pSS的白细胞减少（55.6％,20/36）、淋巴细胞减少（77.8％,28/36）、ANA阳性（80.5％,29/36）、补体C3降低（50.0％,18/36）的发生率均显著高于ALA阴性组,差异有统计学意义（x2值分别为8.296,25.348,3.929,3.866,P均＜0.05）.③在143例pSS患者中,淋巴细胞减少的发生率为46.2％（66/143）.ALA阳性、白细胞减少、血小板减少、抗SSB抗体阳性、补体C3降低在淋巴细胞减少组中更为常见（x2=27.496,51.344,5.320,8.950,7.782; P＜0.05）.结论 ALA可能是pSS患者中淋巴细胞减少的重要血清标志物,在SS的临床诊治中有重要意义.Objective To investigate the relationship between anti-lymphocyte antibody （ALA） and clinical and immunological parameters in primary Sj（o）gren syndrome （pSS）.The significance of ALA and lymphopenia in pSS was explored.Methods Serum samples were obtained from 143 patients with pSS.Clinical and laboratory data were collected.Sera from 45 healthy individuals were collected as the controls.Serum ALA IgG was detected by indirect immunofluorescence test （IIFT）.x2 test and t test were used for statistical analysis.The reasons of lymphopenia in pSS patients were analyzed.The correlation between ALA,lymphopenia and clinical manifestations as well as laboratory parameters was analyzed.Results ① Of the 143 pSS patients,25.2%（36/143） were serological positive for ALA,which was significantly higher than the normal group （6.5%,5/77） （x2=27.496,P〈O.01）.② The prevalence of leukopenia （55.6%,20/36）,lymphopenia （77.8%,28/36）,anti-nuclear antibody（80.5%,29/36） and C3 decrease（50.0%,18/36） was higher in pSS patients with ALA than those without （x2=8.296,25.348,3.929,3.866,P〈0.05）.③ 46.2%（66/143） patients had lymphopenia.Comparing with patients with normal lymphocyte count,the incidence of ALA positive,leukopenia,PLT decrease and anti-SSB antibodies positivity was significantly higher in patients with lymphopenia （x2=27.496,51.344,5.320,8.950,7.782; P〈0.05）.Conclusion The ALA is likely to be a meaningful sera marker for pSS patients with lymphopenia,and this suggests that it has an important role in the clinical progress of SS.

关 键 词：抗淋巴细胞血清 干燥综合征 淋巴细胞减少 

分 类 号：R593.2[医药卫生—内科学]