2型糖尿病24 h尿钠排泄与脂代谢关系研究  

Relationship between 24-h urinary sodium and lipid metabolism in patients with type 2 diabetes

作　　者：陈珏材 赵志钢[1] 何洪波[1] 钟健[1] 祝之明[1] 闫振成[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所高血压内分泌科全军高血压代谢病中心重庆市高血压研究所,重庆400042

出　　处：《中国实用内科杂志》2014年第4期360-363,共4页Chinese Journal of Practical Internal Medicine

基　　金：国家重点基础研究发展计划(2012CB517805);第三军医大学临床医学重大科研项目(2012XLC08);重庆市科技攻关项目(CSTC2019gg-yyjs10062)

摘　　要：目的探讨2型糖尿病患者24h尿钠与脂代谢的关系。方法收集2012年9月至2013年7月第三军医大学大坪医院200例2型糖尿病住院患者一般资料，测定血脂、空腹血糖、24h尿钠等生化指标。采用单因素方差分析、Logistic回归分析等方法分析尿钠排泄与脂代谢的关系。结果按24h尿钠四分位数分为低尿钠组、中尿钠组、中高尿钠组、高尿钠组，四组三酰甘油呈逐渐增高趋势，高尿钠组三酰甘油[1．87mmol／L（1．24～3．93mm01／L）]显著高于低尿钠组[1．43mmol／L（1．13—2．20mmol／L），P=0．015]，Logistic回归分析提示尿钠排泄增多是高三酰甘油血症的独立危险因素[OR（95％CI）：1．006（1．001，1．010），P=0．010]。结论高盐膳食是2型糖尿病患者高三酰甘油血症的重要危险因素，控制钠盐摄入可能有助于改善糖尿病患者血脂紊乱。Objective To explore the relationship between 24-h urinary sodium and lipid metabolism in patients with type 2 diabetes. Methods Two hundred in-patients with type 2 diabetes were enrolled and 24-h urinary sodium, fasting blood glu- cose and lipid parameters were measured. One-way ANOVA and Logistic regression analysis were performed to investigate the impacts of 24-h urinary sodium on dyslipidemia. Results The subjects were divided into 4 groups according to quartiles of the 24-h urinary sodium. There was an increasing trend in triglycerides among the four groups. The concentration of plas- ma triglyceride was significantly higher in patients with the highest quartile of the 24-h urinary sodium than that with the lowest urinary sodium （ 1.87 [ 1.24 - 3.93] mmol/L vs 1.43[1. 13 - 2. 20 ] mmol/L,P = 0. 015 ）. Logistic regression analy- sis showed that 24-h urinary sodium was the independent risk of hyperlipidemia in type 2 diabetes （ OR[ 95% CI] ： 1. 006 [ 1. 001,1. 010] ,P = 0. 010）. Conclusion High salt intake may be an important risk factor in hypertriglyceridemia and control of sodium intake will prevent dyslipidemia in patients with type 2 diabetes.

关 键 词：尿钠 血脂 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]