五灵脂低温超微粉碎特性考察  

Investigation of Cryogenic Pulverization Properties of Faeces Trogopterori

作　　者：王小平[1,3] 韩丽[1] 任桂林[1] 柯刚[1] 张定堃[1] 黄攀[1] 杨明[1,2] 

机构地区：[1]成都中医药大学,中药资源系统研究与开发利用重点实验室,成都611137 [2]江西中医学院,现代中药制剂教育部重点实验,南昌330004 [3]江西中医药高等专科学校,江西抚州344000

出　　处：《中国实验方剂学杂志》2014年第8期1-4,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81274098)

摘　　要：目的:研究五灵脂的粉体学性质,探讨其粉体学性质与体外溶出行为的相关性。方法:采用振动式低温超微粉碎机对五灵脂进行粉碎,每3 min取样,检测样品粒径、比表面积、孔隙率;以总黄酮含量为指标,考察五灵脂粉体的体外溶出速率,并分析其粉体学性质与体外溶出行为的相关性。结果:随着粉碎时间的增加,粒径逐渐减小,比表面积及体外溶出速率逐渐增加;粉末粒径与体外溶出速率具有良好相关性。五灵脂粉碎时间选择21 min,粒径以d0.9约100μm为宜。结论:五灵脂低温超微粉碎后粒子形态及结构均匀,溶出速率快,有助于后续制剂工艺及质量控制的评价。Objective：To study powder properties of Faeces Trogopterori and investigate relativity between powder properties and in vitro dissolution behavior.Method：Faeces Trogopterori was crushed by vibration type low temperature ultrafine pulverizer,sampling every 3 min,particle size,specific surface area and porosity of samples were detected ; With the content of total flavonoids as index,in vitro dissolution rate of Faeces Trogopterori powder was investigated,relativity between powder properties and in vitro dissolution behavior was analyzed.Result：With increasing grinding time,particle size decreased,specific surface area and in vitrodissolution rate increased; Powder size and in vitro dissolution rate had a good correlation.Grinding time of Faeces Trogopterori selected 21 min,but particle size of d0.9 should choose was about 100 μm.Conclusion：After low-temperature ultrafine ground of Faeces Trogopterori,particle morphology and structurewas uniform with high dissolution rate,which was helpful forits subsequent evaluation of preparation process and quality control.

关 键 词：粒径 比表面积 孔隙率 吸附-脱附等温线 溶出速率 五灵脂 粉体学特性 

分 类 号：R283.2[医药卫生—中药学] R283.6[医药卫生—中医学]