2-氨磺酰基-4-甲磺酰氨基甲基苯甲酸甲酯的合成  

Synthesis of Benzoic Acid, 2-(Aminosulfonyl)-4-[[(methylsulfonyl)amino] methyl]-, Methyl Ester

作　　者：李纪兴[1] 孙克[1] 于春睿[1] 武恩明[1] 于福强[1] 薛有仁 叶艳明[1] 

机构地区：[1]沈阳化工研究院有限公司新农药创制与开发国家重点实验室,沈阳110021

出　　处：《农药》2014年第4期239-241,共3页Agrochemicals

摘　　要：[目的]甲磺胺磺隆是一种高效、广谱、低毒、高选择性的磺酰脲类除草剂。综述甲磺胺磺隆重要中间体2-氨磺酰基-4-甲磺酰氨基甲基苯甲酸甲酯的合成方法,并对其中一种合成路线进行详细的研究。[方法]以对甲苯腈为起始原料,经过硝化、氧化、酯化、加氢、磺酰化、重氮化和氨化7步反应得到产物。[结果]在优化的反应条件下,以对甲苯腈计总收率可达31.3%。[结论]该工艺路线具有反应条件温和、产品纯度高、易于实现工业化生产等特点。[Aims] Mesosulfuran-methyl is one of sulfonylureaherbicides with good efficacy, broad spectrum, low toxicity for the non-targeted species and high selectivity. The synthesis of benzoic acid, 2-（aminosulfonyl）-4-[[（methylsulfonyl） amino]methyl]-, methyl ester, the important intermediate, was introduced in this paper. One of the methods was researched in detail. [Methods] It is synthesized in sequence by nitration, oxidation, esterification, hydrogenation, sulfination, diazotization and ammonolysis using 4-methylbenzonitril as the starting material. [Results] The total yield was 31.3% based on 4-methylbenzonitrile under the optimized reaction conditions. [Conclusions] The method has many advantages of mild reaction condition, high selectivity and purity, which is suitable for industrial production.

关 键 词：磺酰脲类除草剂 甲磺胺磺隆 合成 

分 类 号：TQ457.2[化学工程—农药化工]