氟虫腈酰胺化衍生物的合成及其对柞蚕饰腹寄蝇病防治效果  

Synthesis of Fipronil Amide Derivatives and Its Application in Protection of Atheraea Perny from Parasitic Flies

作　　者：牛雄雷[1] 杨金琛[1] 张惠淳[1] 董绪国[1] 宋策[1] 王立石[1] 黄均伟[1] 陈连清[2] 晏立衡 陈贵娣[2] 

机构地区：[1]辽宁省蚕业科学研究所,辽宁凤城118100 [2]中南民族大学催化材料科学国家民委-教育部共建重点实验室,武汉430074

出　　处：《农药》2014年第4期245-247,286,共4页Agrochemicals

基　　金：国家现代产业技术体系建设项目(CARS-22-SYZ02);辽宁省蚕业科学研究所与中南民族大学合作项目(HZY12001);国家自然科学基金(20702064和21177161);湖北省杰出青年基金(2013CFA034);人事部留学人员科技活动择优资助项目(BZY13007);武汉市青年科技晨光计划(201271031422)

摘　　要：[目的]通过对氟虫腈的结构改造,开发新型柞蚕饰腹寄蝇病防治药剂。[方法]以氟虫腈为先导化合物,经NaH处理、与相应的酰氯反应,合成6种酰胺化衍生产物,测定它们对柞蚕的毒性及对柞蚕饰腹寄蝇病防效。[结果]其结构经红外光谱、核磁、质谱和元素分析确证。将氟虫腈酰胺化衍生物用于柞蚕寄蝇防治,结果表明其毒性降低,对寄蝇病的防效最高可达69%。[结论]合成氟虫腈酰胺化衍生物并应用于柞蚕保护领域,取得较好防效,为开发基于苯基吡唑类结构的新型柞蚕饰腹寄蝇病防治药剂的分子设计奠定一定基础。[Aims] In order to develop new pesticides for protecting atheraea perny from parasitic flies larva, the modification of fipronil was conducted. [Methods] Using flpronil as the iead compound, the title compounds were obtained by treatment with Nail and amidation with corresponding amide chloride. In order to evaluate their bio-activity, toxicity tests and activity tests in protect of atheraea perny from parasitic flies larva were carried out. [Results] Their structures were confirmed by IR, NMR, MS and elementary analysis. The results showed that the toxicity of the title compounds to atheraea perny lowered compared to fipronil and the bio-control activity amounted to 69% control effect. [Conclusions] The synthesis of fipronil amide derivatives and their application in protection of atheraea perny from parasitic flies were reported and promising activity was obtained, which will provide a base for further molecular design.

关 键 词：氟虫腈 酰胺化衍生物 柞蚕 寄蝇 防治 

分 类 号：TQ453.2[化学工程—农药化工]