农吉利碱凝胶剂的质量评价及初步稳定性研究  

Quality assessment and preliminary study on stability of monocrotaline gel

作　　者：刘会[1] 章德军[2] 黄绳武[1] 熊阳[1] 

机构地区：[1]浙江中医药大学药学院,浙江杭州310053 [2]浙江大学医学院附属儿童医院,浙江杭州310003

出　　处：《山西中医学院学报》2014年第1期23-25,共3页Journal of Shanxi College of Traditional Chinese Medicine

基　　金：浙江省中医药管理局青年教师资助项目(2010ZQ001);国家自然科学基金青年基金项目(81202926);浙江省科技厅现代中药制剂及其重点关键技术研究科技创新团队资助项目(2012R10044-09)

摘　　要：目的:建立农吉利碱凝胶剂质量标准,并进行初步稳定性考察。方法:通过含量测定、体外透皮试验、初步稳定性考察对农吉利碱凝胶剂进行综合评价。结果:农吉利碱在1.6μg/mL^102.4μg/mL的浓度范围内线性关系良好,平均回收率为100.75%,RSD为0.82%(n=6)。结论:建立的质量评价方法专属性良好,准确可靠,能有效控制农吉利碱凝胶剂的质量。Objective：To establish quality standards of monocrotaline gel and conduct preliminary stability test. Methods：Comprehensive evaluation on monocrotaline gel was underwent through content determination ,diadermic test and prelimi-nary stability test. Result：Monocrotaline had good linearity in the range of 1.6 μg/mL^102.4 μg/mL. The average recovery rate was 100.75% and RSD was 0.82%（n=6）. Conclusion：The method of quality evaluation established is specific,accu-rate and reliable,and can effectively control the quality of monocrotaline gel.

关 键 词：农吉利碱凝胶剂 质量评价 初步稳定性 

分 类 号：R927.11[医药卫生—药学]