MICA抗体对移植肾功能的影响  

The influence of MICA antibody on the function of transplant kidney

作　　者：贾保祥[1] 武俊杰[1] 田野[1] 

机构地区：[1]首都医科大学附属北京友谊医院泌尿科,北京100050

出　　处：《国际检验医学杂志》2014年第7期815-816,共2页International Journal of Laboratory Medicine

基　　金：北京友谊医院科研启动基金资助项目(2009-24)

摘　　要：目的研究肾移植术后患者抗主要组织相容性复合物I类相关链A(MICA)抗体与移植肾存活的关系。方法选择经检测证实群体反应性抗体(PRA)阴性的153例肾移植患者为该组研究对象。于2009年12月检测MICA抗体,而后观察3年后肾移植患者肾功能变化。结果 153例肾移植患者中,14例MICA抗体阳性,占9.2%;139例MICA抗体阴性,占90.8%。MICA抗体阳性患者肾功能异常率明显高于MICA抗体阴性患者(χ2=64.70,P<0.01)。结论 MICA抗体是引起移植肾慢性失功能的重要因素之一。Objective To study the relationship between major-histocompatibility-complex class I related chain A （MICA） anti- body and the function of transplant kidney. Methods 153 transplant patients who showed PRA negative were involved in this as- say. MICA test was done in 2009 and the kidney function was observed after 3 year transplantation. Results Among the 153 pa- tients,MICA antibody showed positive in 14 patients（9.2%） and showed negative in 139 patients（90.8%）. The rate of abnormal renal function in patients with MICA antibody positive was high then that in patients with MICA antibody negative（ Х^2= 64. 70, P〈0.01）. Conclusion MICA antibody is one of the important factors that cause chronic transplant renal function loss.

关 键 词：肾移植 移植肾功能 

分 类 号：R699.2[医药卫生—泌尿科学]