肺结核患者血清IL-23和IL-22检测及临床意义  

Expression and clinical significance of serum IL-23 and IL-22 on patients with pulmonary tuberculosis

作　　者：叶宁华 曾今诚[2] 罗勇强 林东子 

机构地区：[1]东莞市中医院,广东东莞523000 [2]广东医学院广东省医学分子诊断重点实验室,广东东莞523808 [3]东莞市慢性病防治院,广东东莞523008

出　　处：《国际检验医学杂志》2014年第7期817-818,821,共3页International Journal of Laboratory Medicine

基　　金：广东省医学科研基金资助项目(B2013427);东莞市医疗卫生科技计划(20131051010139)

摘　　要：目的研究肺结核(PTB)患者血清IL-23和IL-22水平并分析其临床意义。方法检测47例PTB患者和26名健康志愿者(HV组)外周血血清IL-23和IL-22水平,并分析其相关性。结果 PTB患者血清IL-22水平明显低于HV组(P<0.05),常规化疗药物治疗前PTB患者血清IL-22水平明显低于治疗后(P<0.05),结核分枝杆菌反应阳性患者血清IL-22水平明显低于阴性患者(P<0.05);PTB患者血清IL-23水平明显低于HV组(P<0.05),治疗前PTB患者IL-23水平明显低于治疗后(P<0.05),结核分枝杆菌反应阳性患者血清IL-23水平明显低于反应阴性患者(P<0.05)。Pearson相关性分析显示,PTB患者血清IL-22水平和IL-23水平无明显相关性(P>0.05),但结核分枝杆菌反应阳性患者血清IL-23水平与IL-22水平呈正相关(P<0.05)。结论 IL-23和IL-22均在抗结核免疫过程中发挥重要作用。Objective To study serum IL-23 and IL-22 levels and analysis its clinical significance in pulmonary tuberculosis （PTB） patients. Methods ELISA was used to detect serum IL-23 and IL-22 levels in 47 PTB patients and 26 healthy volunteers （HV group）. Pearson correlation analysis was used to analyze the correlation of them. Results Serum IL-22 level of PTB group was significantly lower than that in HV group （P〈0. 05）. Serum IL-22 level of PTB group was significantly increased after treat- ment（P〈0.05）. Serum IL-22 level of sputum smear-positive PTB group was significantly lower than that in sputum smear-negative PTB group （P〈0. 05）. Serum IL-23 level of PTB group was also significantly lower than that in HV group （P〈0. 05）. And serum IL-23 level of PTB group was significantly increased after treatment（P〈0.05）. Serum IL-23 level of sputum smear-positive PTB group was significantly lower than that in sputum smear-negative PTB group （P〈0. 05）. The correlation analysis showed that there was no correlated between serum IL-23 and IL-22 levels on PTB patients（P〈0.05）, but there was positively correlated be- tween serum IL-23 and IL-22 levels on sputum smear-positive PTB patients（P〈0.05）. Conclusion IL-23 and IL-22 may play a more important role in PTB development.

关 键 词：肺结核 白细胞介素23 白细胞介素22 

分 类 号：R521[医药卫生—内科学]